OPN1LW and TICAM2

Number of citations of the paper that reports this interaction (PMID 14517278)
187

Data Source:
HPRD (in vitro)

		OPN1LW	TICAM2
Gene Name		opsin 1 (cone pigments), long-wave-sensitive	toll-like receptor adaptor molecule 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Photoreceptor Outer Segment Membrane	Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Endosome Membrane Early Endosome Membrane Late Endosome Membrane
	Molecular Function	G-protein Coupled Receptor Activity Photoreceptor Activity	Signal Transducer Activity Phospholipid Binding
	Biological Process	Retinoid Metabolic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Visual Perception Phototransduction, Visible Light Protein-chromophore Linkage Positive Regulation Of Cytokinesis	Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Response To Interleukin-12 Cellular Response To Lipopolysaccharide Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Interleukin-18-mediated Signaling Pathway
Pathways			Activated TLR4 signalling Toll-Like Receptors Cascades TRAF6 mediated induction of TAK1 complex IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade TRIF-mediated programmed cell death MyD88-independent cascade Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: NCOA2 PIAS3 RANBP2 TICAM2	18 interactors: FTH1 IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 MEOX2 OPN1LW PIAS2 SARM1 TICAM1 TIRAP TLR3 TLR4 TRAF6
Entrez ID		5956	353376
HPRD ID		02366	16313
Ensembl ID		ENSG00000102076	ENSG00000243414
Uniprot IDs			Q86XR7
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptidyl-lysine Modification Protein Sumoylation Regulation Of Glucose Metabolic Process Response To Organic Substance Positive Regulation Of Interleukin-18-mediated Signaling Pathway Regulation Of Carbohydrate Metabolic Process Peptidyl-amino Acid Modification Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production TRAM-dependent Toll-like Receptor 4 Signaling Pathway Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Response To Interleukin-12 Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Glucokinase Activity Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Sumoylation Regulation Of Protein Sumoylation RNA Biosynthetic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Response To Cytokine Mitotic Nuclear Envelope Disassembly Regulation Of Toll-like Receptor Signaling Pathway Nuclear Envelope Disassembly Positive Regulation Of Receptor Activity Positive Regulation Of Membrane Potential Positive Regulation Of Chemokine Production Regulation Of Gluconeogenesis Positive Regulation Of Interferon-gamma Production RNA Metabolic Process Cellular Protein Modification Process Response To Hormone Regulation Of Chemokine Production I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway Gene Expression MyD88-independent Toll-like Receptor Signaling Pathway Nuclear Envelope Organization Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Interleukin-6 Production Glucose Transport	Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Interferon-beta Production Immune System Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Cytokine Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Interferon-beta Production Regulation Of Immune System Process Cytokine-mediated Signaling Pathway Defense Response Cellular Response To Molecule Of Bacterial Origin Response To Cytokine Response To Other Organism Response To Bacterium Response To Biotic Stimulus Response To Lipopolysaccharide Lipopolysaccharide-mediated Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Organic Substance Response To Molecule Of Bacterial Origin Regulation Of Type I Interferon Production Regulation Of Interleukin-6 Production Regulation Of Cytokine Biosynthetic Process Cellular Response To Interleukin-1 Positive Regulation Of Interferon-alpha Production Cellular Response To Organic Substance Toll-like Receptor 9 Signaling Pathway
Tagcloud ?			advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb tlr4 tlr6 tollip tuberculin uganda
Tagcloud (Difference) ?			advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb tlr4 tlr6 tollip tuberculin uganda
Tagcloud (Intersection) ?