TGIF2

Gene Name		TGFB-induced factor homeobox 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Centrosome
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Gastrulation Nodal Signaling Pathway Positive Regulation Of Neuron Differentiation Retina Development In Camera-type Eye
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: HDAC1 RBBP8 SMAD3 TARBP2
Entrez ID		60436
HPRD ID		06293
Ensembl ID		ENSG00000118707
Uniprot IDs		Q9GZN2
PDB IDs
Enriched GO Terms of Interacting Partners?		Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Gene Expression, Epigenetic Gene Silencing By MiRNA Cellular Response To DsRNA Negative Regulation Of Gene Expression Posttranscriptional Gene Silencing Gene Silencing By RNA Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Transcription Response To DsRNA Negative Regulation Of Cellular Metabolic Process Gene Silencing Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transforming Growth Factor Beta3 Production Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Cellular Response To Transforming Growth Factor Beta Stimulus RNA Metabolic Process Response To Transforming Growth Factor Beta Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Gene Expression DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Targeting Of MRNA For Destruction Involved In RNA Interference Evasion Or Tolerance Of Host Defenses By Virus DNA-templated Transcription, Initiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Biosynthetic Process Cell Cycle Production Of SiRNA Involved In RNA Interference Regulation Of Extracellular Matrix Assembly Primary MiRNA Processing Negative Regulation Of Protein Phosphorylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process SMAD Protein Complex Assembly Negative Regulation Of Osteoblast Proliferation Regulation Of RNA Metabolic Process RNA Interference DNA Double-strand Break Processing Camera-type Eye Development
Tagcloud ?		arap3 axillary bioinformatic ccnb2 chromatid cin25 cytoskeleton dissemination drive frameshift frozen insertions intratumoral nanoball ngs nodal node overlapping pds5b pipeline poorer progressed rearrangements segregate segregation sister snvs substitutions top2a