PSMB5 and ABCB5

Number of citations of the paper that reports this interaction (PubMedID 15488952)
0

Data Source:
HPRD (two hybrid)

		PSMB5	ABCB5
Description		proteasome 20S subunit beta 5	ATP binding cassette subfamily B member 5
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Extracellular Exosome	Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Nucleotide Binding ATP Binding ABC-type Xenobiotic Transporter Activity Efflux Transmembrane Transporter Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	Proteolysis Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasome Assembly Proteolysis Involved In Protein Catabolic Process	Eye Development Cell Differentiation Regulation Of Membrane Potential Xenobiotic Transport Transmembrane Transport
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	ABC-family proteins mediated transport
Drugs		Bortezomib (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Carfilzomib	Biricodar Dofequidar
Diseases
GWAS		High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 34103634 32296059 31959851 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Dental caries ( 23259602) Eosinophil count ( 29403010) Femur bone mineral density x serum urate levels interaction ( 34046847) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Prostate cancer ( 23535732) Response to statin therapy ( 20339536) Type 1 diabetes ( 34127860) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		28 interacting genes: ABCB5 BAG4 CCDC150 CLP1 DUSP29 GAGE12G GAGE2E IKBKG LSM1 NTAQ1 PIK3R1 PLK1 POMP PRNP PSMA1 PSMA2 PSMA3 PSMB1 PSMB3 PSMB4 PSMB7 PSMG3 TAP1 TAP2 TCHP TRAF6 UBD XRN1	8 interacting genes: CCND2 CD44 EPHA2 ERBB2 FGFR4 PSMB5 RAF1 STK11
Entrez ID		5693	340273
HPRD ID		02629	12402
Ensembl ID		ENSG00000100804	ENSG00000004846
Uniprot IDs		A0A140VJS7 P28074	Q2M3G0
PDB IDs		4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5L5W 5L5X 5L5Y 5L5Z 5L60 5L61 5L62 5L63 5L64 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ 7LXV 7NAN 7NAO 7NAP 7NAQ 7NHT 7PG9 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7V5G 7V5M 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8BZL 8CVR 8CVS 8CVT 8CXB 8QYN 8QYO 8QYS 8QZ9 8TM6 8UD9 8YIX 8YIY 8YIZ 9E8G 9E8O 9E8Q 9HMN
Enriched GO Terms of Interacting Partners?		Proteasome Core Complex Proteasome Complex Proteasome Core Complex, Beta-subunit Complex Proteasome Core Complex, Alpha-subunit Complex Cytosol Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Peptide Transmembrane Transporter Activity ABC-type Peptide Antigen Transporter Activity TAP Complex Macromolecule Catabolic Process ABC-type Peptide Transporter Activity Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process TAP1 Binding Cytosol To Endoplasmic Reticulum Transport MHC Class Ib Protein Binding ABC-type Transporter Activity Protein Catabolic Process MHC Protein Binding MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Protein Localization To Cell Periphery Antigen Processing And Presentation Of Peptide Antigen Proteasome Assembly Cytoplasm Histone MRNA Catabolic Process Proteolysis P-body Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Myeloid Dendritic Cell Differentiation Antigen Processing And Presentation Catabolic Process Regulation Of Immune Response Histone MRNA Metabolic Process Myeloid Dendritic Cell Activation Nucleus Secretory Granule Lumen Antigen Processing And Presentation Of Endogenous Antigen Ficolin-1-rich Granule Lumen Protein Metabolic Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Macromolecule Metabolic Process Type 8 Metabotropic Glutamate Receptor Binding Lipopolysaccharide Binding Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Tapasin Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Kinase Activity Positive Regulation Of Catalytic Activity ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Protein Phosphorylation Phosphorylation Protein Tyrosine Kinase Activity Positive Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Schwann Cell Development Lamellipodium Membrane Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway Epithelial Cell Proliferation Regulation Of Catalytic Activity Receptor Complex Carbohydrate Homeostasis Glucose Homeostasis Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Phosphorylation Phosphate-containing Compound Metabolic Process ATP Binding Positive Regulation Of Phosphorylation Regulation Of Cellular Component Organization Growth Factor Binding Cell Population Proliferation Regulation Of Lamellipodium Organization Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Response To Growth Factor Positive Regulation Of Phosphate Metabolic Process Apoptotic Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Regulation Of Anatomical Structure Morphogenesis Glial Cell Development Negative Regulation Of Programmed Cell Death Nucleotide Binding Transferase Activity Notochord Cell Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Wound Healing Positive Regulation Of Protein Modification Process
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