TAF5 and CPSF1

Number of citations of the paper that reports this interaction (PubMedID 9311784)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		TAF5	CPSF1
Description		TATA-box binding protein associated factor 5	cleavage and polyadenylation specific factor 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Factor TFIID Complex Nucleolus Actin Cytoskeleton Transcription Factor TFTC Complex	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex
	Molecular Function	Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Identical Protein Binding	Nucleic Acid Binding RNA Binding Protein Binding Enzyme Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Regulation Of DNA Repair DNA-templated Transcription Initiation Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	MRNA Processing RNA 3'-end Processing Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Transport of Mature mRNA Derived from an Intronless Transcript tRNA processing in the nucleus mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Height ( 31562340) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Schizophrenia ( 23974872 25056061)	Educational attainment ( 25201988)
Interacting Genes		16 interacting genes: CPSF1 GTF2F2 H3-4 TAF1 TAF10 TAF11 TAF12 TAF15 TAF2 TAF4 TAF6 TAF7 TAF8 TAF9 TBP UBE2I	58 interacting genes: CSTF2T GLIS2 HMOX1 IL7R INCA1 MCM2 MIR1-2 MIR106B MIR107 MIR122 MIR128-2 MIR138-1 MIR138-2 MIR143 MIR155 MIR15A MIR15B MIR16-2 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR29A MIR31 MIR34A MIR34B MIR7-1 MIR92A1 MIR92A2 MIR98 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I NEDD4 PAPOLA POLR2A PRRC2A REL TAF11 TAF12 TAF13 TAF5 TAF7 UBC
Entrez ID		6877	29894
HPRD ID		11876	05823
Ensembl ID		ENSG00000148835	ENSG00000071894
Uniprot IDs		Q15542	Q10570
PDB IDs		2NXP 6F3T 6MZC 6MZD 6MZL 6MZM 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGG 7EGI 7EGJ 7ENA 7ENC 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	6BLY 6BM0 6DNH 6F9N 6FUW 6URG 6URO 8E3I 8E3Q 8R8R
Enriched GO Terms of Interacting Partners?		RNA Polymerase II General Transcription Initiation Factor Activity Transcription Factor TFIID Complex DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase II Promoter MRNA Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly MRNA Transcription Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Protein-DNA Complex Assembly Transcription By RNA Polymerase II Transcription Factor TFTC Complex DNA-templated Transcription MRNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process RNA Metabolic Process Macromolecule Biosynthetic Process Protein Heterodimerization Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Nucleoplasm MLL1 Complex Positive Regulation Of RNA Metabolic Process Protein-containing Complex Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of DNA Repair Cellular Component Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II SAGA Complex Positive Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Aryl Hydrocarbon Receptor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Male Germ Cell Nucleus Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Metabolic Process	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Angiogenesis Regulation Of Gene Expression Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Motility Negative Regulation Of Locomotion MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cytokine Production Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Negative Regulation Of Signal Transduction Regulation Of Endothelial Cell Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of RNA Stability Extracellular Space Regulation Of Translation Negative Regulation Of Cell Communication
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