TAC1 and TFF2

Number of citations of the paper that reports this interaction (PMID 11786503)
7

Data Source:
BioGRID (pull down)

		TAC1	TFF2
Gene Name		tachykinin, precursor 1	trefoil factor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Axon Neuronal Cell Body	Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Substance P Receptor Binding	Protein Binding CXCR4 Chemokine Receptor Binding
	Biological Process	Positive Regulation Of Acute Inflammatory Response Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Synaptic Transmission Insemination Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Negative Regulation Of Heart Rate Positive Regulation Of Epithelial Cell Migration Sensory Perception Of Pain Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Positive Regulation Of Renal Sodium Excretion Response To Morphine Positive Regulation Of Action Potential Positive Regulation Of Ossification Positive Regulation Of Saliva Secretion Response To Pain Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Corticosterone Secretion	Digestion Positive Regulation Of Cell Proliferation Calcium-mediated Signaling Regulation Of Cell Migration Negative Regulation Of Macrophage Activation Negative Regulation Of Inflammatory Response Negative Regulation Of Gastric Acid Secretion Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Tachykinin receptors bind tachykinins Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Adverse response to radiation therapy ( 23719583) Response to platinum-based agents ( 22020760)
Protein-Protein Interactions		12 interactors: ARHGEF40 BAG6 CENPB FN1 MEP1A PREP TAC4 TACR1 TACR2 TACR3 TFF2 XRCC6	2 interactors: FCRL4 TAC1
Entrez ID		6863	7032
HPRD ID		08876	01682
Ensembl ID		ENSG00000006128	ENSG00000160181
Uniprot IDs		P20366 Q9Y494	Q03403
PDB IDs		2B19 2KS9 2KSA 2KSB
Enriched GO Terms of Interacting Partners?		Tachykinin Receptor Signaling Pathway Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Saliva Secretion Regulation Of Smooth Muscle Contraction Operant Conditioning Regulation Of Saliva Secretion Hyperosmotic Salinity Response Neuropeptide Signaling Pathway Blood Circulation Positive Regulation Of Digestive System Process Positive Regulation Of Vascular Permeability Regulation Of Muscle Contraction Hyperosmotic Response Regulation Of Blood Pressure Regulation Of Vascular Permeability Response To Salt Stress Positive Regulation Of Blood Pressure Response To Morphine Regulation Of Secretion Response To Electrical Stimulus Excretion Smooth Muscle Contraction Positive Regulation Of Secretion Positive Regulation Of Acetylcholine Secretion, Neurotransmission Acute Inflammatory Response Response To Osmotic Stress Response To Ammonium Ion Positive Regulation Of Synaptic Transmission Cellular Hyperosmotic Salinity Response Smooth Muscle Contraction Involved In Micturition Intestine Smooth Muscle Contraction Negative Regulation Of Luteinizing Hormone Secretion Angiotensin-mediated Drinking Behavior Response To Abiotic Stimulus Digestion Response To Estradiol G-protein Coupled Receptor Signaling Pathway Regulation Of Acetylcholine Secretion, Neurotransmission Calcium-independent Cell-matrix Adhesion Learning Positive Regulation Of Synaptic Transmission, Cholinergic Response To Alkaloid Synaptic Transmission Prolactin Secretion Cellular Response To X-ray Negative Regulation Of Gastric Acid Secretion Negative Regulation Of Gonadotropin Secretion Micturition Response To Ozone	Positive Regulation Of Corticosterone Secretion Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Saliva Secretion Regulation Of Corticosterone Secretion Regulation Of Synaptic Transmission, Cholinergic Regulation Of Saliva Secretion Positive Regulation Of Action Potential Tachykinin Receptor Signaling Pathway Negative Regulation Of Heart Rate Positive Regulation Of Digestive System Process Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Synaptic Transmission, GABAergic Insemination Regulation Of Renal Sodium Excretion Copulation Negative Regulation Of Heart Contraction Regulation Of Excretion Positive Regulation Of Acute Inflammatory Response Regulation Of Synaptic Transmission, GABAergic Response To Pain Response To Morphine Positive Regulation Of Stress Fiber Assembly Long-term Memory Positive Regulation Of Actin Filament Bundle Assembly Mating Positive Regulation Of Lipid Transport Regulation Of Stress Fiber Assembly Regulation Of Acute Inflammatory Response Regulation Of Heart Rate Positive Regulation Of Epithelial Cell Migration Associative Learning Multicellular Organismal Response To Stress Sensory Perception Of Pain Response To Ammonium Ion Regulation Of Lipid Transport Neuropeptide Signaling Pathway Positive Regulation Of Inflammatory Response Positive Regulation Of Ossification Positive Regulation Of Hormone Secretion Positive Regulation Of Synaptic Transmission Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Memory Learning Regulation Of Epithelial Cell Migration Response To Alkaloid Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Regulation Of Heart Contraction Detection Of Abiotic Stimulus
Tagcloud ?		1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hspa2 hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tmod1 xecd	achieve cohesin coincides communication connect depending depletion derive directionality distal distant division enhancer enriched erbb1 estrogen facilitates facilitator influenced mcf7 modulates myc promoters repressing restrict situated tff1 tmprss3 universal
Tagcloud (Difference) ?		1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hspa2 hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tmod1 xecd	achieve cohesin coincides communication connect depending depletion derive directionality distal distant division enhancer enriched erbb1 estrogen facilitates facilitator influenced mcf7 modulates myc promoters repressing restrict situated tff1 tmprss3 universal
Tagcloud (Intersection) ?