XCL2 and KRTAP1-3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		XCL2	KRTAP1-3
Description		X-C motif chemokine ligand 2	keratin associated protein 1-3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR Chemokine Receptor Binding	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction Blood Circulation Positive Regulation Of Cell Migration Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (q) signalling events	Keratinization
Drugs
Diseases
GWAS		Emphysema imaging phenotypes ( 26030696) Lung cancer ( 28604730) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		19 interacting genes: CCL2 CCL20 CCL21 CCL26 CCL28 CCL5 CCL7 CCL8 CXCL12 CXCL17 CXCL2 CXCL3 CXCL5 KRTAP1-3 KRTAP10-9 NOTCH2NLA PF4 PF4V1 XCR1	183 interacting genes: ADAM12 AGA ALDH3B1 ALPP ATG9A BCAM BHLHE40 BMP7 BTC C19orf25 C2orf68 CATSPER1 CELF5 CHIC2 CHRD CHRNG CLDN2 CMTM8 CNNM3 COA5 COL8A1 CRCT1 CREB5 CRH CRY2 CTNNBIP1 CXCL16 CYP21A2 CYSRT1 DAGLB DHRS1 DLGAP3 DMRT3 DOCK2 ECE1 EMC7 FBXW5 FZD10 GLP1R GLRX3 GLYAT GNE GRAP2 GSTP1 HCK HHEX HHIPL1 HOXA1 HOXB9 HOXC8 HPCAL1 HSD3B7 IGSF8 IL10 IL16 INPP5D INS ITGB4 ITGB5 JOSD1 KLHL38 KLK8 KPRP KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LONRF1 LRFN4 MAPKBP1 MOS MTNR1A MXD3 MXI1 MYPOP NAXD NECTIN2 NECTIN3 NID2 NMU NPBWR2 NPDC1 NR1D2 NUFIP2 OLFM2 OTX1 P3H3 PDE9A PDIA5 PHETA1 PHLDA1 PIGS PLEKHN1 PRF1 PRKAA2 PRKAB2 PRPF31 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAMAC RANBP3 RASD1 RPN1 RPS19BP1 SAPCD2 SDC3 SDCBP SELENOM SHFL SLC13A5 SLC22A23 SLC23A1 SLC39A7 SLC43A2 SLC5A5 SLC7A11 SMCP SPINT1 SPRY1 STK16 SUSD6 TACSTD2 TCAF1 TFAP2D TGFB1 THAP7 TNS2 UNC119 UTP23 UXT VASN VSTM4 WNT11 XCL2 YIPF3 YY1 ZDHHC1 ZFTRAF1 ZNF330 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF587 ZNF696 ZNF764 ZNF786 ZNF837
Entrez ID		6846	81850
HPRD ID		05317	12305
Ensembl ID		ENSG00000143185	ENSG00000221880
Uniprot IDs		Q9UBD3	Q8IUG1
PDB IDs
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Antimicrobial Humoral Response Locomotion Leukocyte Chemotaxis Cytokine Activity Leukocyte Migration Humoral Immune Response Granulocyte Chemotaxis Myeloid Leukocyte Migration Granulocyte Migration Cell Migration Inflammatory Response Cell Motility Defense Response To Symbiont Defense Response To Other Organism Mononuclear Cell Migration Immune Response Chemokine-mediated Signaling Pathway Eosinophil Chemotaxis Eosinophil Migration Defense Response Response To Other Organism CCR Chemokine Receptor Binding Immune System Process Extracellular Space Killing Of Cells Of Another Organism Regulation Of Leukocyte Migration CXCR Chemokine Receptor Binding Extracellular Region Response To External Biotic Stimulus Positive Regulation Of Leukocyte Migration Positive Regulation Of Mononuclear Cell Migration Cell Killing Monocyte Chemotaxis Regulation Of Lymphocyte Migration Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Cytokine-mediated Signaling Pathway Chemokine Receptor Binding Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Lymphocyte Migration Regulation Of Chemotaxis Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Cell Motility Negative Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Locomotion	Epidermis Development Keratinization Protein Binding Intermediate Filament Keratin Filament Tissue Development Hair Cycle Susceptibility To T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Animal Organ Morphogenesis Negative Regulation Of Defense Response Identical Protein Binding
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