PRKD3

Description		protein kinase D3
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Ciliary Basal Body
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Sphingolipid Biosynthetic Process Intracellular Signal Transduction
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Alzheimer's disease ( 34099642) Body mass index ( 28892062) Chronic lymphocytic leukemia ( 24292274 28165464) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Pulse pressure ( 27841878) Schizophrenia ( 23974872 33169155) Systolic blood pressure ( 27841878 28135244)
Novel Interacting Genes		1 novel interacting genes: DYNLL2
Interacting Genes		12 interacting genes: BCL6 DLAT GSK3A IKBKG KPNA2 KPNB1 MYH3 NUDT3 POLL SKA2 TAF1 VAMP2
Entrez ID		23683
HPRD ID		06151
Ensembl ID		ENSG00000115825
Uniprot IDs		O94806
PDB IDs		2D9Z
Enriched GO Terms of Interacting Partners?		NLS-dependent Protein Nuclear Import Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process NLS-bearing Protein Import Into Nucleus Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity Negative Regulation Of Mitotic Cell Cycle DNA Replication Somatic Diversification Of Immunoglobulins Positive Regulation Of Proteolysis Negative Regulation Of UDP-glucose Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Establishment Of Spindle Localization Mitotic Metaphase Chromosome Alignment Positive Regulation Of Androgen Receptor Signaling Pathway Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol Diphosphate Pentakisphosphate Diphosphatase Activity Diphosphoinositol Polyphosphate Catabolic Process Myosin V Complex Nucleobase-containing Compound Metabolic Process Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Mitotic Cell Cycle DNA Replication DNA Damage Response Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Mast Cell Cytokine Production Isotype Switching To IgE Isotypes Negative Regulation Of Plasma Cell Differentiation Intronic Transcription Regulatory Region Sequence-specific DNA Binding Dihydrolipoyllysine-residue Acetyltransferase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Metaphase Chromosome Alignment Chromosome Localization Establishment Of Organelle Localization Spindle Localization Spindle Assembly Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Negative Regulation Of Protein Autoubiquitination Linear Polyubiquitin Binding 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] Diphosphatase Activity Diphosphoinositol Polyphosphate Metabolic Process Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Bis(5'-adenosyl)-hexaphosphatase Activity Diadenosine Hexaphosphate Catabolic Process Inositol Phosphate Catabolic Process Diadenosine Pentaphosphate Catabolic Process Adenosine 5'-(hexahydrogen Pentaphosphate) Catabolic Process Diphosphoinositol-polyphosphate Diphosphatase Activity
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