SULT1B1 and SULT2A1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SULT1B1	SULT2A1
Gene Name		sulfotransferase family, cytosolic, 1B, member 1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Cytosol
	Molecular Function	Aryl Sulfotransferase Activity Sulfotransferase Activity	Protein Binding Sulfotransferase Activity Bile-salt Sulfotransferase Activity
	Biological Process	Cellular Biogenic Amine Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Flavonoid Metabolic Process Phenol-containing Compound Metabolic Process Epithelial Cell Differentiation Thyroid Hormone Metabolic Process Small Molecule Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation	Xenobiotic Metabolic Process Digestion Steroid Metabolic Process Bile Acid Catabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Cytosolic sulfonation of small molecules Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	PPARA activates gene expression Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Fatty acid, triacylglycerol, and ketone body metabolism Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Metabolism of lipids and lipoproteins Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Cytosolic sulfonation of small molecules Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs			Dehydroepiandrosterone Adenosine-3\'-5\'-Diphosphate Aetiocholanolone Mercury Diiodide
Diseases
GWAS			Dehydroepiandrosterone sulphate levels ( 21533175)
Protein-Protein Interactions		4 interactors: POT1 SDCBP SULT2A1 SULT2B1	5 interactors: PRDX4 STAT3 STK3 SULT1B1 TMX1
Entrez ID		27284	6822
HPRD ID		07088	00502
Ensembl ID			ENSG00000105398
Uniprot IDs		O43704	A8K015 Q06520
PDB IDs		2Z5F 3CKL	1EFH 1J99 1OV4 2QP3 2QP4 3F3Y 4IFB
Enriched GO Terms of Interacting Partners?		3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Positive Regulation Of DNA Strand Elongation Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Sulfate Assimilation Telomere Formation Via Telomerase Bile Acid Catabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly Purine Nucleoside Metabolic Process Steroid Metabolic Process Positive Regulation Of Helicase Activity Regulation Of Extracellular Vesicular Exosome Assembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Ribonucleotide Metabolic Process Nucleoside Metabolic Process Purine Nucleotide Metabolic Process Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Ribose Phosphate Metabolic Process Sulfur Compound Metabolic Process Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Organelle Organization Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Substrate-dependent Cell Migration, Cell Extension Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Nucleotide Metabolic Process Positive Regulation Of DNA Biosynthetic Process Sulfation RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Steroid Catabolic Process Positive Regulation Of Organelle Assembly Nucleobase-containing Small Molecule Metabolic Process Telomere Maintenance Via Telomere Lengthening Substrate-dependent Cell Migration Bile Acid Metabolic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Regulation Of Organelle Organization Positive Regulation Of Exocytosis Organophosphate Metabolic Process	Negative Regulation Of Male Germ Cell Proliferation Negative Regulation Of Cell Proliferation Cell Redox Homeostasis Regulation Of Male Germ Cell Proliferation Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Phosphate-containing Compound Metabolic Process Negative Regulation Of Locomotion Cellular Modified Amino Acid Metabolic Process Regulation Of Developmental Growth Protein Folding Reproductive Process Negative Regulation Of Glycolytic Process Cellular Response To Stimulus Homeostatic Process Primitive Hemopoiesis Radial Glial Cell Differentiation Regulation Of Cell Proliferation Protein Maturation By Protein Folding Interleukin-6-mediated Signaling Pathway I-kappaB Phosphorylation 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Regulation Of Axon Regeneration Endocardium Development Hepatocyte Apoptotic Process Sulfation Reproductive Structure Development Phosphorylation Intracellular Signal Transduction Reproductive System Development 4-hydroxyproline Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Stimulus Growth Hormone Receptor Signaling Pathway Temperature Homeostasis Flavonoid Metabolic Process Cellular Response To Growth Hormone Stimulus Cellular Response To Interleukin-6 Regulation Of Glycolytic Process Positive Regulation Of Notch Signaling Pathway Thyroid Hormone Metabolic Process Regulation Of Cell Migration Hippo Signaling Eating Behavior Negative Regulation Of Neuron Migration Regulation Of Growth Regulation Of Cell Motility
Tagcloud ?		17p 20q 8p 8q aberration abhd12 abhd2 affymetrix arhgdib cna copy crc cxcl6 deployed integrating loc440995 oit3 omics organizing rab12 ralbp1 rnmt s1000a2 s100a2 sty tokyo tyms ugt2b28 written	23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 lama3 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rassf2 rhamm tff top2a
Tagcloud (Difference) ?		17p 20q 8p 8q aberration abhd12 abhd2 affymetrix arhgdib cna copy crc cxcl6 deployed integrating loc440995 oit3 omics organizing rab12 ralbp1 rnmt s1000a2 s100a2 sty tokyo tyms ugt2b28 written	23h1 aberrations birc5 ccne2 ctsb dab2 ddx15 dismal egr1 etv4 eya4 gata3 gltscr2 hmmr itgb4 kcnk12 lama3 licam2 loxl2 metastasize mmp13 mpnst mpnsts msh2 pdgfra rassf2 rhamm tff top2a
Tagcloud (Intersection) ?