STXBP2 and STX3

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		STXBP2	STX3
Description		syntaxin binding protein 2	syntaxin 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Plasma Membrane Apical Plasma Membrane Secretory Granule Specific Granule Azurophil Granule Zymogen Granule Membrane Cytolytic Granule Phagocytic Vesicle Extracellular Exosome Tertiary Granule Presynapse	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Vacuole Plasma Membrane Cell-cell Junction Endomembrane System Membrane Apical Plasma Membrane Lamellipodium Secretory Granule Dendrite Growth Cone SNARE Complex Melanosome Specific Granule Azurophil Granule Zymogen Granule Membrane Neuron Projection Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse Plasma Membrane Bounded Cell Projection
	Molecular Function	Protein Binding Syntaxin-1 Binding Syntaxin Binding Syntaxin-3 Binding	SNARE Binding SNAP Receptor Activity Protein Binding Arachidonate Binding
	Biological Process	Leukocyte Mediated Cytotoxicity Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Protein Transport Vesicle-mediated Transport Regulation Of Mast Cell Degranulation Neutrophil Degranulation Regulated Exocytosis Cellular Response To Type II Interferon Presynaptic Dense Core Vesicle Exocytosis	Neurotransmitter Transport Intracellular Protein Transport Exocytosis Vesicle Fusion Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Vesicle-mediated Transport Neuron Projection Development Positive Regulation Of Cell Adhesion Vesicle Docking Modulation Of Chemical Synaptic Transmission Positive Regulation Of Chemotaxis Long-term Synaptic Potentiation Membrane Fusion Organelle Membrane Fusion Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface
Pathways		Platelet degranulation Other interleukin signaling	Other interleukin signaling
Drugs
Diseases
GWAS			High chromosomal aberration frequency (chromosome type) ( 31586183)
Interacting Genes		14 interacting genes: DDX20 FILNC1 GEMIN2 GEMIN4 SMN1 SNAP23 SNRPB SNRPD2 SNRPD3 STX1A STX2 STX3 STXBP3 VAMP2	54 interacting genes: AQP6 CD79A COQ9 CPLX2 CPLX4 CREB3L1 CYB561 DNAJC5 EBAG9 ELOVL4 ERGIC3 EVI5 FAM209A FXYD3 GPR152 GPX8 JAGN1 LMNA MANBAL MGST3 MMGT1 MSMO1 MTIF3 NAPB PGRMC2 REEP4 RMDN3 SCN3B SLC10A6 SLC35H1 SLC71A2 SNAP23 SNAP25 SNAP29 STX1A STX2 STX4 STX5 STXBP1 STXBP2 SYT1 SYT4 SYT7 TBC1D30 TMEM14B TMPPE TMX2 TRPC3 TXLNA UBC VAMP3 VAMP7 VAMP8 ZDHHC15
Entrez ID		6813	6809
HPRD ID		03423	15985
Ensembl ID		ENSG00000076944	ENSG00000166900
Uniprot IDs		Q15833 Q53GF4	A0A286YF28 Q13277 Q53YE2
PDB IDs		4CCA
Enriched GO Terms of Interacting Partners?		SMN-Sm Protein Complex Spliceosomal SnRNP Assembly SNAP Receptor Activity SMN Complex Protein-RNA Complex Assembly Gemini Of Cajal Bodies SNARE Complex Spliceosomal Complex Assembly Small Nuclear Ribonucleoprotein Complex Protein-containing Complex Assembly RNA Splicing Exocytosis Vesicle Fusion Cellular Component Assembly Organelle Membrane Fusion Protein-containing Complex Organization 7-methylguanosine Cap Hypermethylation MRNA Processing Organelle Fusion U4 SnRNP Methylosome Vesicle Organization Membrane Fusion Vesicle Docking Specific Granule SNARE Binding MRNA Metabolic Process Organelle Localization By Membrane Tethering U1 SnRNP Secretion By Cell U5 SnRNP RNA Splicing, Via Transesterification Reactions Membrane Docking Vesicle-mediated Transport In Synapse U2-type Prespliceosome Assembly U12-type Spliceosomal Complex U2 SnRNP Secretory Granule U2-type Spliceosomal Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex U2-type Catalytic Step 2 Spliceosome Secretion Synaptic Vesicle Exocytosis RNA Processing Calcium-ion Regulated Exocytosis Histone Pre-mRNA DCP Binding Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex U4/U6 X U5 Tri-snRNP Complex Neuron Projection	Exocytosis SNARE Complex Secretion By Cell SNARE Binding Vesicle Fusion Syntaxin Binding Organelle Membrane Fusion Organelle Localization By Membrane Tethering SNAP Receptor Activity Secretion Membrane Docking Organelle Fusion Regulated Exocytosis Synaptic Vesicle Exocytosis Membrane Fusion Vesicle Docking Vesicle Organization Membrane Signal Release Calcium-ion Regulated Exocytosis Vesicle-mediated Transport Positive Regulation Of Regulated Secretory Pathway Vesicle-mediated Transport In Synapse Syntaxin-1 Binding Calcium Ion-regulated Exocytosis Of Neurotransmitter Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Organelle Localization Regulation Of Regulated Secretory Pathway SNARE Complex Assembly Positive Regulation Of Exocytosis Regulation Of Exocytosis Neurotransmitter Transport Membrane Organization Regulation Of Vesicle Fusion Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Secretion By Cell Establishment Of Localization In Cell Vesicle Docking Involved In Exocytosis Regulation Of Secretion Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Secretory Granule Regulation Of Vesicle-mediated Transport Synaptic Vesicle Membrane Organization Presynaptic Dense Core Vesicle Exocytosis Regulation Of Transport Regulation Of Calcium Ion-dependent Exocytosis Phagocytic Vesicle Membrane Synaptic Vesicle Priming Secretory Granule Localization
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