SSTR4 and SST

Number of citations of the paper that reports this interaction (PMID 8100352)
2

Data Source:
HPRD (in vivo)

		SSTR4	SST
Gene Name		somatostatin receptor 4	somatostatin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection	Extracellular Region Extracellular Space Neuronal Cell Body
	Molecular Function	Somatostatin Receptor Activity Neuropeptide Binding	Hormone Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Synaptic Transmission Negative Regulation Of Cell Proliferation Cell Migration Arachidonic Acid Metabolic Process Negative Regulation Of CAMP Metabolic Process Forebrain Development Somatostatin Signaling Pathway Positive Regulation Of MAPK Cascade Cellular Response To Glucocorticoid Stimulus	Hyperosmotic Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Synaptic Transmission Response To Nutrient Digestion Negative Regulation Of Cell Proliferation Hormone-mediated Apoptotic Signaling Pathway Response To Heat Regulation Of Cell Migration Response To Drug Response To Amino Acid Response To Steroid Hormone
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Cysteamine
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: CORT SST	6 interactors: PDIA2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
Entrez ID		6754	6750
HPRD ID		01676	08920
Ensembl ID		ENSG00000132671	ENSG00000157005
Uniprot IDs		P31391	P61278
PDB IDs			1P2W
Enriched GO Terms of Interacting Partners?		Hormone-mediated Apoptotic Signaling Pathway Synaptic Transmission Cell-cell Signaling Hyperosmotic Response G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway	Somatostatin Signaling Pathway Cellular Response To Estradiol Stimulus Neuropeptide Signaling Pathway Cellular Response To Estrogen Stimulus Hormone-mediated Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Organic Cyclic Compound Response To Estradiol Cellular Response To Lipid Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Steroid Hormone Response To Peptide Response To Glucocorticoid Response To Corticosteroid Cellular Response To Hormone Stimulus Synaptic Transmission Response To Estrogen Negative Regulation Of Cell Proliferation Response To Organonitrogen Compound Response To Lipid Response To Organic Cyclic Compound Cell-cell Signaling Response To Hormone G-protein Coupled Receptor Signaling Pathway Forebrain Development Cerebellum Development Metencephalon Development Regulation Of Cell Proliferation Hindbrain Development Response To Starvation Brain Development Cellular Response To Organic Substance Head Development Central Nervous System Development Response To Organic Substance Response To Nutrient Levels Response To Extracellular Stimulus Spermatogenesis Male Gamete Generation Cell Surface Receptor Signaling Pathway Digestion Gamete Generation Cellular Response To Stimulus Sexual Reproduction
Tagcloud ?		arrays breast cohort component correlated correlation distribution epidermal estrogen evaluate hypothalamic independent interested luminal marker markers materials micro population principal produced sample somatostatin sstr2 subtype subtypes tma tumors	additional allow alphac barley cdna cerevisiae encoding entry fructan fructosyltransferase fusion hordeum incubated methylotrophic pastoris pichia ppicz produced pronounced saccharomyces secreted secretory sft sucrose transformed translational vector vulgare yeast
Tagcloud (Difference) ?		arrays breast cohort component correlated correlation distribution epidermal estrogen evaluate hypothalamic independent interested luminal marker markers materials micro population principal sample somatostatin sstr2 subtype subtypes tma tumors	additional allow alphac barley cdna cerevisiae encoding entry fructan fructosyltransferase fusion hordeum incubated methylotrophic pastoris pichia ppicz pronounced saccharomyces secreted secretory sft sucrose transformed translational vector vulgare yeast
Tagcloud (Intersection) ?		produced