SSTR4 and SST

Number of citations: 0 (PubMedID 8100352)
Data Source: HPRD (in vivo)

		SSTR4	SST
Name		somatostatin receptor 4	somatostatin
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Neuron Projection	Extracellular Region Extracellular Space Cytosol Neuronal Cell Body GABA-ergic Synapse Neuronal Dense Core Vesicle
	Molecular Function	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Protein Binding Neuropeptide Binding	Hormone Activity Protein Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Negative Regulation Of Cell Population Proliferation Somatostatin Signaling Pathway Cellular Response To Glucocorticoid Stimulus	Hyperosmotic Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Response To Nutrient Digestion Negative Regulation Of Cell Population Proliferation Hormone-mediated Apoptotic Signaling Pathway Response To Xenobiotic Stimulus Response To Acidic PH Regulation Of Cell Migration Somatostatin Signaling Pathway Response To Amino Acid Response To Steroid Hormone Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events MECP2 regulates transcription of neuronal ligands
Drugs		Somatostatin Lutetium Lu 177 dotatate	None
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Blood sugar levels ( 29403010 ) Hypothyroidism ( 27182965 ) Mitochondrial DNA copy number ( 30704525 ) Obesity-related traits ( 23251661 ) Vitamin D levels ( 26704534 )	Pursuit maintenance gain ( 29064472 ) Skin pigmentation ( 28300201 )
Novel Interactors		None recorded	1 novel interactors: FXR1
Interacting Genes		2 interacting genes: CORT SST	6 interacting genes: PDIA2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
Entrez ID		6754	6750
HPRD ID		01676	08920
Ensembl ID		ENSG00000132671	ENSG00000157005
Uniprot IDs		P31391	P61278
PDB IDs		7XMS 7XMT	2MI1 7T10 7WIC 7WJ5 7XAT 7XMR 7XMS 7Y27
GO Terms Enriched among Interactors		Receptor Ligand Activity Hormone Activity Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Somatostatin Signaling Pathway Hormone-mediated Apoptotic Signaling Pathway Signaling Cell-cell Signaling Cell Communication G Protein-coupled Receptor Signaling Pathway Neuropeptide Hormone Activity Regulation Of Cell Motility Regulation Of Cell Migration Digestion Neuronal Dense Core Vesicle Response To Acidic PH Hyperosmotic Response Regulation Of Locomotion Response To PH Extracellular Space G Protein-coupled Receptor Binding Response To Osmotic Stress Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway GABA-ergic Synapse Response To Amino Acid Extracellular Region Response To Nutrient Hormone-mediated Signaling Pathway Response To Steroid Hormone Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway	Somatostatin Receptor Activity Somatostatin Signaling Pathway Neuropeptide Binding G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Neuron Projection Hormone-mediated Signaling Pathway G Protein-coupled Receptor Activity Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Negative Regulation Of Cell Population Proliferation G Protein-coupled Receptor Signaling Pathway Cellular Response To Steroid Hormone Stimulus Response To Glucocorticoid Cellular Response To Lipid Response To Corticosteroid Response To Steroid Hormone Cellular Response To Estradiol Stimulus Response To Lipid Regulation Of Cell Population Proliferation Cellular Response To Hormone Stimulus Response To Estradiol Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Response To Hormone Hormone-mediated Apoptotic Signaling Pathway RNA Strand Annealing Activity Nuclear Pore Localization Intracellular Membraneless Organelle Protein Retention In ER Lumen Positive Regulation Of Long-term Neuronal Synaptic Plasticity Disulfide Oxidoreductase Activity Nuclear Pore Complex Assembly Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Maintenance Of Protein Localization In Endoplasmic Reticulum Protein Folding In Endoplasmic Reticulum Nuclear Pore Organization Costamere Ribonucleoprotein Granule Translation Regulator Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Pore Complex Assembly Skeletal Muscle Organ Development Protein Disulfide Isomerase Activity