SRP19 and ATG12

		SRP19	ATG12
Description		signal recognition particle 19	autophagy related 12
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Nuclear Body Signal Recognition Particle Ribonucleoprotein Complex	Autophagosome Membrane Nucleoplasm Cytoplasm Autophagosome Cytosol Membrane Phagocytic Vesicle Membrane Protein-containing Complex Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Transferase Complex
	Molecular Function	RNA Binding Protein Binding 7S RNA Binding Ribosome Binding	Protein Binding Atg8-family Ligase Activity Protein Tag Activity
	Biological Process	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition	Autophagosome Assembly Autophagy Of Mitochondrion Autophagy Macroautophagy Negative Regulation Of Type I Interferon Production Piecemeal Microautophagy Of The Nucleus Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus Glycophagy Autophagosome Maturation Regulation Of Autophagosome Maturation Positive Regulation Of Viral Translation
Pathways		SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane	Macroautophagy Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS			Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		9 interacting genes: APP CEBPA IPO5 IPO7 IPO8 KPNA1 MAPK8IP2 SRP54 TNPO1	18 interacting genes: APP ATG10 ATG3 ATG5 ATG7 CRX DOCK9 IER2 KRTAP4-12 MDFI MEOX2 NLRP6 PLSCR1 PRKACA PTK2 RB1CC1 SERTAD1 SERTAD2
Entrez ID		6728	9140
HPRD ID		01644	08496
Ensembl ID		ENSG00000153037	ENSG00000145782
Uniprot IDs		A0A087WYR0 A0A2U3TZN1 P09132	O94817
PDB IDs		1JID 1MFQ 1RY1 2J37 3KTV 4P3E 5M73 7NFX 7QWQ	4GDK 4GDL 4NAW
Enriched GO Terms of Interacting Partners?		Intracellular Protein Transport Protein Import Into Nucleus Import Into Nucleus Establishment Of Protein Localization To Organelle Protein Localization To Nucleus Intracellular Transport Nuclear Transport Nucleocytoplasmic Transport Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Cellular Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Nuclear Pore Small GTPase Binding Intracellular Protein Localization Protein Localization To Organelle Mating Behavior NLS-bearing Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Granulocyte Differentiation Reproductive Behavior Modulation Of Excitatory Postsynaptic Potential Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Learning Or Memory Amylin Binding Positive Regulation Of Toll Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cognition Protein-containing Complex Acetylcholine Receptor Activator Activity Axo-dendritic Transport Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Cell Cycle Response To Vitamin B2 C/EBP Complex Positive Regulation Of Viral Translation Regulation Of Defense Response PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development	Autophagy Of Mitochondrion Nucleophagy Autophagosome Assembly Autophagosome Organization Macroautophagy Vacuole Organization Piecemeal Microautophagy Of The Nucleus Atg12 Transferase Activity Negative Regulation Of Phagocytosis Microautophagy Atg8-family Ligase Activity Regulation Of Phagocytosis Phagophore Assembly Site Positive Regulation Of Metabolic Process Defense Response To Virus Autophagy Regulation Of Endocytosis Atg12-Atg5-Atg16 Complex Mitophagy Regulation Of Mucus Secretion Response To Virus Negative Regulation Of Endocytosis Cellular Response To Nitrogen Starvation Cellular Component Assembly Glycophagy Vascular Endothelial Cell Response To Fluid Shear Stress Cytoplasm Cytosol Response To Lead Ion Ubiquitin-like Protein Transferase Activity Glycogen Catabolic Process Regulation Of Vesicle-mediated Transport Phagophore Assembly Site Membrane Positive Regulation Of Catabolic Process Axoneme Polysaccharide Catabolic Process Molecular Function Activator Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of JNK Cascade Postsynaptic Modulation Of Chemical Synaptic Transmission Cellular Response To Fluid Shear Stress Regulation Of Metabolic Process Regulation Of Autophagy Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway
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