SPINK1 and CTRC

Number of citations of the paper that reports this interaction (PMID 2093478)
1

Data Source:
HPRD (in vitro)

		SPINK1	CTRC
Gene Name		serine peptidase inhibitor, Kazal type 1	chymotrypsin C (caldecrin)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding	Serine-type Endopeptidase Activity Peptidase Activity
	Biological Process	Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Acrosome Reaction Negative Regulation Of Calcium Ion Import Negative Regulation Of Serine-type Endopeptidase Activity Regulation Of Store-operated Calcium Entry	Proteolysis
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: CTRC ELN NRSN1 TMPRSS15	8 interactors: KRTAP10-3 KRTAP10-7 NEDD8 PHKG1 SERPINA3 SPINK1 ST13 UBC
Entrez ID		6690	11330
HPRD ID		01341	03242
Ensembl ID		ENSG00000164266	ENSG00000162438
Uniprot IDs		P00995	Q99895
PDB IDs		1CGI 1CGJ 1HPT	4H4F
Enriched GO Terms of Interacting Partners?			Glycogen Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Cellular Polysaccharide Biosynthetic Process Polysaccharide Biosynthetic Process Glycogen Metabolic Process Polysaccharide Metabolic Process Regulation Of Proteolysis Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Glucose Metabolic Process Carbohydrate Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Metabolic Process Response To Transforming Growth Factor Beta Negative Regulation Of Protein Refolding Pathogenesis Hexose Metabolic Process Negative Regulation Of Calcium Ion Import Chaperone Cofactor-dependent Protein Refolding Cellular Carbohydrate Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Monosaccharide Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Serine-type Endopeptidase Activity Protein Neddylation Negative Regulation Of Serine-type Peptidase Activity Regulation Of Acrosome Reaction Viral Protein Processing Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Generation Of Precursor Metabolites And Energy Regulation Of Store-operated Calcium Entry Glycogen Catabolic Process Protein Refolding Epithelial Structure Maintenance Polysaccharide Catabolic Process Regulation Of Calcium Ion Import Notch Receptor Processing
Tagcloud ?		3d amenable biopsy burden chd1 circulating diversity enable erg exome feature foxa1 genomics hampered methodology modifier mutational organoid pharmacologic pik3r1 progress prostate rb recapitulate repertoire shared spop success tmprss2	a73t acinar acini adenovirus ar42j became bip carrying characterised chop chymotrypsinogen considerably destruction detached dexamethasone ebp elicit exocrine freshly immunoglobulin judged mediator pancreas pancreatitis parenchymal permanent propensity tunel xbp1
Tagcloud (Difference) ?		3d amenable biopsy burden chd1 circulating diversity enable erg exome feature foxa1 genomics hampered methodology modifier mutational organoid pharmacologic pik3r1 progress prostate rb recapitulate repertoire shared spop success tmprss2	a73t acinar acini adenovirus ar42j became bip carrying characterised chop chymotrypsinogen considerably destruction detached dexamethasone ebp elicit exocrine freshly immunoglobulin judged mediator pancreas pancreatitis parenchymal permanent propensity tunel xbp1
Tagcloud (Intersection) ?