SPINK1 and TMPRSS15

Number of citations of the paper that reports this interaction (PMID 2093478)
1

Data Source:
HPRD (in vitro)

		SPINK1	TMPRSS15
Gene Name		serine peptidase inhibitor, Kazal type 1	transmembrane protease, serine 15
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome	Brush Border Integral Component Of Membrane
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding	Serine-type Endopeptidase Activity Scavenger Receptor Activity
	Biological Process	Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Acrosome Reaction Negative Regulation Of Calcium Ion Import Negative Regulation Of Serine-type Endopeptidase Activity Regulation Of Store-operated Calcium Entry	Proteolysis Receptor-mediated Endocytosis
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Bulimia nervosa ( 23568457)
Protein-Protein Interactions		4 interactors: CTRC ELN NRSN1 TMPRSS15	1 interactors: SPINK1
Entrez ID		6690	5651
HPRD ID		01341	05972
Ensembl ID		ENSG00000164266	ENSG00000154646
Uniprot IDs		P00995	P98073
PDB IDs		1CGI 1CGJ 1HPT	4DGJ
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of Calcium Ion Import Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Regulation Of Acrosome Reaction Regulation Of Store-operated Calcium Entry Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transport Negative Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Ion Transport Regulation Of Exocytosis Regulation Of Calcium Ion Transport Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Phosphorylation Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Vesicle-mediated Transport Regulation Of Endopeptidase Activity Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Negative Regulation Of Intracellular Signal Transduction Regulation Of Ion Transmembrane Transport Regulation Of Cellular Ketone Metabolic Process Regulation Of Ion Transport Regulation Of Secretion Regulation Of Proteolysis
Tagcloud ?		3d amenable biopsy burden chd1 circulating diversity enable erg exome feature foxa1 genomics hampered methodology modifier mutational organoid pharmacologic pik3r1 progress prostate rb recapitulate repertoire shared spop success tmprss2
Tagcloud (Difference) ?		3d amenable biopsy burden chd1 circulating diversity enable erg exome feature foxa1 genomics hampered methodology modifier mutational organoid pharmacologic pik3r1 progress prostate rb recapitulate repertoire shared spop success tmprss2
Tagcloud (Intersection) ?