SPINK1 and TMPRSS15

Number of citations of the paper that reports this interaction (PubMedID 2093478)
0

Data Source:
HPRD (in vitro)

		SPINK1	TMPRSS15
Description		serine peptidase inhibitor Kazal type 1	transmembrane serine protease 15
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Brush Border Membrane
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Nitric Oxide Mediated Signal Transduction Negative Regulation Of Nitric Oxide Mediated Signal Transduction Sperm Capacitation Regulation Of Acrosome Reaction Negative Regulation Of Calcium Ion Import Regulation Of Store-operated Calcium Entry	Proteolysis
Pathways		Developmental Lineage of Pancreatic Acinar Cells
Drugs
Diseases		Hereditary pancreatitis; Hereditary chronic pancreatitis Tropical calcific pancreatitis	Enterokinase deficiency
GWAS		Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)	Asthma ( 29273806) Bulimia nervosa ( 23568457) Nucleus accumbens volume in trauma-exposed individuals ( 29187748)
Interacting Genes		6 interacting genes: ASPH CTRC ELN NRSN1 TMPRSS15 UBE3A	1 interacting genes: SPINK1
Entrez ID		6690	5651
HPRD ID		01341	05972
Ensembl ID		ENSG00000164266	ENSG00000154646
Uniprot IDs		P00995	P98073
PDB IDs		1CGI 1CGJ 1HPT 7QE8 7QE9	4DGJ 6ZOV 7WQX
Enriched GO Terms of Interacting Partners?		Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Intracellular Chemical Homeostasis Monoatomic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Intracellular Monoatomic Cation Homeostasis Serine-type Peptidase Activity Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Ribonucleoside-diphosphate Reductase Activity Sperm Entry Regulation Of Golgi Lumen Acidification Positive Regulation Of Golgi Lumen Acidification Cellular Homeostasis Activation Of Store-operated Calcium Channel Activity Elastic Fiber Serine-type Endopeptidase Activity Positive Regulation Of G0 To G1 Transition Purine Nucleotide Binding Positive Regulation Of Cellular PH Reduction Positive Regulation Of Store-operated Calcium Channel Activity Intracellular Calcium Ion Homeostasis Positive Regulation Of Protein Localization To Lysosome	Phosphoribosylamine-glycine Ligase Activity Phosphoribosylformylglycinamidine Cyclo-ligase Activity Phosphoribosylglycinamide Formyltransferase Activity Ligase Activity, Forming Carbon-nitrogen Bonds Adenine Biosynthetic Process Negative Regulation Of Nitric Oxide Mediated Signal Transduction Adenine Metabolic Process
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