SPINK1

Description		serine peptidase inhibitor Kazal type 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Nitric Oxide Mediated Signal Transduction Negative Regulation Of Nitric Oxide Mediated Signal Transduction Sperm Capacitation Regulation Of Acrosome Reaction Negative Regulation Of Calcium Ion Import Regulation Of Store-operated Calcium Entry
Pathways		Developmental Lineage of Pancreatic Acinar Cells
Drugs
Diseases		Hereditary pancreatitis; Hereditary chronic pancreatitis Tropical calcific pancreatitis
GWAS		Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)
Novel Interacting Genes		1 novel interacting genes: RRM1
Interacting Genes		6 interacting genes: ASPH CTRC ELN NRSN1 TMPRSS15 UBE3A
Entrez ID		6690
HPRD ID		01341
Ensembl ID		ENSG00000164266
Uniprot IDs		P00995
PDB IDs		1CGI 1CGJ 1HPT 7QE8 7QE9
Enriched GO Terms of Interacting Partners?		Peptidyl-aspartic Acid 3-dioxygenase Activity Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Intracellular Chemical Homeostasis Monoatomic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Intracellular Monoatomic Cation Homeostasis Serine-type Peptidase Activity Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Ribonucleoside-diphosphate Reductase Activity Sperm Entry Regulation Of Golgi Lumen Acidification Positive Regulation Of Golgi Lumen Acidification Cellular Homeostasis Activation Of Store-operated Calcium Channel Activity Elastic Fiber Serine-type Endopeptidase Activity Positive Regulation Of G0 To G1 Transition Purine Nucleotide Binding Positive Regulation Of Cellular PH Reduction Positive Regulation Of Store-operated Calcium Channel Activity Intracellular Calcium Ion Homeostasis Positive Regulation Of Protein Localization To Lysosome
Tagcloud ?