SPATS1 and CFLAR

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SPATS1	CFLAR
Gene Name		spermatogenesis associated, serine-rich 1	CASP8 and FADD-like apoptosis regulator
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Cytoplasm Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Membrane Raft Ripoptosome
	Molecular Function		Protease Binding Cysteine-type Endopeptidase Activity Death Receptor Binding Protein Binding Enzyme Activator Activity Protein Complex Binding Death Effector Domain Binding
	Biological Process		Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Development Skeletal Muscle Atrophy Regulation Of Satellite Cell Proliferation Skeletal Myofibril Assembly Viral Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Skeletal Muscle Tissue Regeneration Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Necroptotic Process Negative Regulation Of Myoblast Fusion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Death Receptor Signalling TRAIL signaling Programmed Cell Death Extrinsic Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CFLAR GPHN SPG7	24 interactors: BCL2L1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 DAXX DEDD DEDD2 FADD IKBKB MAP2K4 MAP2K7 NFKB1 PSEN2 RAF1 RIPK1 RIPK2 SMAD3 SPATS1 TNFRSF10B TRAF1 TRAF2
Entrez ID		221409	8837
HPRD ID		10248	04671
Ensembl ID		ENSG00000249481	ENSG00000003402
Uniprot IDs		Q496A3	B4E361 E9PAP3 O15519
PDB IDs			3H11 3H13
Enriched GO Terms of Interacting Partners?		Glycine Receptor Clustering Molybdenum Incorporation Into Molybdenum-molybdopterin Complex Establishment Of Synaptic Specificity At Neuromuscular Junction Negative Regulation Of Myoblast Fusion Skeletal Muscle Atrophy Striated Muscle Atrophy Muscle Atrophy Regulation Of Satellite Cell Proliferation Skeletal Myofibril Assembly Skeletal Muscle Adaptation Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Molybdopterin Cofactor Biosynthetic Process Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Negative Regulation Of Myotube Differentiation Regulation Of Necroptotic Process Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Myoblast Fusion Regulation Of Necrotic Cell Death Skeletal Muscle Tissue Regeneration Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Anterograde Axon Cargo Transport Postsynaptic Membrane Organization System Development Negative Regulation Of Muscle Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Axon Cargo Transport Receptor Clustering Tissue Regeneration Neuromuscular Junction Development Regulation Of Myotube Differentiation Multicellular Organismal Development Anatomical Structure Development Myofibril Assembly Synapse Assembly Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Water-soluble Vitamin Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Proteolysis Regulation Of Striated Muscle Cell Differentiation Developmental Process Protein Metabolic Process Zymogen Activation	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Intracellular Signal Transduction Toll-like Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Protein Processing Activation Of Innate Immune Response Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Signal Transduction Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Signal Transduction Regulation Of Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Endopeptidase Activity Signaling Cell Communication Positive Regulation Of Peptidase Activity Regulation Of Innate Immune Response Regulation Of Endopeptidase Activity Immune Response Regulation Of Peptidase Activity Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?			als2cr11 als2cr12 ancestry bcac casp8 comprising consortium custom dense european exclusions genotyped genotyping gwas icogs imputed intronic missing participating replicated rs1830298 rs36043647 rs59278883 rs7558475 snps spanning telomeric typed yielding
Tagcloud (Difference) ?			als2cr11 als2cr12 ancestry bcac casp8 comprising consortium custom dense european exclusions genotyped genotyping gwas icogs imputed intronic missing participating replicated rs1830298 rs36043647 rs59278883 rs7558475 snps spanning telomeric typed yielding
Tagcloud (Intersection) ?