SMARCD3 and NR1H4

Number of citations of the paper that reports this interaction (PubMedID 14701856)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		SMARCD3	NR1H4
Description		SWI/SNF related BAF chromatin remodeling complex subunit D3	nuclear receptor subfamily 1 group H member 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm SWI/SNF Complex Brahma Complex NpBAF Complex NBAF Complex	Chromatin Euchromatin Nucleus Nucleoplasm Cytosol Nuclear Speck Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Coregulator Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Signaling Receptor Binding Protein Binding Nuclear Receptor Binding DNA-binding Transcription Factor Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Nuclear Receptor Binding Bile Acid Binding Bile Acid Nuclear Receptor Activity Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Chenodeoxycholic Acid Binding
	Biological Process	Positive Regulation Of Neuroblast Proliferation Heart Morphogenesis Secondary Heart Field Specification Cardiac Right Ventricle Formation Neural Retina Development Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Muscle Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Smooth Muscle Cell Differentiation Regulation Of G0 To G1 Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Glucose Homeostasis Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Cell-cell Junction Assembly Notch Signaling Pathway Bile Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Low-density Lipoprotein Particle Clearance Bile Acid And Bile Salt Transport Cell Differentiation Intracellular Receptor Signaling Pathway Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-17 Production Toll-like Receptor 9 Signaling Pathway Regulation Of Urea Metabolic Process Intracellular Triglyceride Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Nuclear Receptor-mediated Bile Acid Signaling Pathway Glucose Homeostasis Cholesterol Homeostasis Defense Response To Bacterium Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Fatty Acid Homeostasis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Triglyceride Homeostasis Regulation Of Bile Acid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Fatty Acid Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Cholesterol Metabolic Process Cellular Response To Bile Acid Positive Regulation Of Adipose Tissue Development Positive Regulation Of Phosphatidic Acid Biosynthetic Process Positive Regulation Of Glutamate Metabolic Process Positive Regulation Of Ammonia Assimilation Cycle
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Cytoprotection by HMOX1 Heme signaling Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols
Drugs			alpha-Linolenic acid Ursodeoxycholic acid Farnesol Fexaramine Cholic Acid Deoxycholic acid Taurocholic acid Arachidonic Acid Obeticholic acid Chenodeoxycholic acid (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid Myrrh Nidufexor Tropifexor
Diseases
GWAS		Eyebrow thickness ( 26926045) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) IgG glycosylation ( 23382691) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Multiple myeloma ( 27363682 33875642) Red blood cell count ( 32888494)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 29403010) Squamous cell carcinoma ( 23341777)
Interacting Genes		21 interacting genes: ARHGAP1 BCL2L13 CCNE1 ESR1 ESRRA FANCA JUN MAPK14 NR1H4 NR5A1 NR5A2 PBX1 PPARG RARA RARB RARG RORA RXRA SMARCC1 SREBF1 STARD13	15 interacting genes: CASP8 EP300 ESR1 GAPDH GRIN1 H3C1 NCOA1 NCOA6 NCOR2 PPARGC1A RXRA RXRG SIRT1 SMARCD1 SMARCD3
Entrez ID		6604	9971
HPRD ID		03440	04827
Ensembl ID		ENSG00000082014	ENSG00000012504
Uniprot IDs		A0A090N8Z9 Q6STE5	B6ZGS9 F1DAL1 Q96RI1
PDB IDs			1OSH 3BEJ 3DCT 3DCU 3FLI 3FXV 3GD2 3HC5 3HC6 3L1B 3OKH 3OKI 3OLF 3OMK 3OMM 3OOF 3OOK 3P88 3P89 3RUT 3RUU 3RVF 4OIV 4QE8 4WVD 5IAW 5ICK 5Q0I 5Q0J 5Q0K 5Q0L 5Q0M 5Q0N 5Q0O 5Q0P 5Q0Q 5Q0R 5Q0S 5Q0T 5Q0U 5Q0V 5Q0W 5Q0X 5Q0Y 5Q0Z 5Q10 5Q11 5Q12 5Q13 5Q14 5Q15 5Q16 5Q17 5Q18 5Q19 5Q1A 5Q1B 5Q1C 5Q1D 5Q1E 5Q1F 5Q1G 5Q1H 5Q1I 5WZX 5Y1J 5Y44 5Y49 5YXB 5YXD 5YXJ 5YXL 5Z12 6A5W 6A5X 6A5Y 6A5Z 6A60 6HL0 6HL1 6ITM 7D42 7TRB 7VUE 8HBM 8HD3
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Transcription Coregulator Binding Intracellular Receptor Signaling Pathway RNA Polymerase II Transcription Regulator Complex Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Intracellular Signal Transduction Retinoic Acid Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Animal Organ Development Positive Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Nucleoplasm Chromatin Binding Cell Differentiation Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Developmental Process Nuclear Retinoid X Receptor Binding Signal Transduction DNA Binding Response To Lipid Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Glandular Epithelial Cell Development Transcription Cis-regulatory Region Binding DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Gland Development Regulation Of MiRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Positive Regulation Of Metabolic Process Negative Regulation Of Developmental Process	Nuclear Receptor Binding Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Transcription Coactivator Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Rhythmic Process Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nuclear Retinoid X Receptor Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Nuclear Steroid Receptor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Nuclear Receptor-mediated Signaling Pathway Developmental Process Myeloid Cell Differentiation Response To Estradiol Regulation Of RNA Metabolic Process Nucleus Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Glucose Metabolic Process Chromatin Organization Transcription Coregulator Activity Nuclear Estrogen Receptor Binding Nucleobase-containing Compound Biosynthetic Process Regulation Of Multicellular Organismal Process Nervous System Development Cell Differentiation Hormone-mediated Signaling Pathway Regulation Of Thyroid Hormone Receptor Signaling Pathway Hexose Metabolic Process
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