SMARCD3

Description		SWI/SNF related BAF chromatin remodeling complex subunit D3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm SWI/SNF Complex Brahma Complex NpBAF Complex NBAF Complex
	Molecular Function	Transcription Coregulator Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Signaling Receptor Binding Protein Binding Nuclear Receptor Binding DNA-binding Transcription Factor Binding
	Biological Process	Positive Regulation Of Neuroblast Proliferation Heart Morphogenesis Secondary Heart Field Specification Cardiac Right Ventricle Formation Neural Retina Development Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Muscle Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Smooth Muscle Cell Differentiation Regulation Of G0 To G1 Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Cytoprotection by HMOX1 Heme signaling Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS		Eyebrow thickness ( 26926045) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) IgG glycosylation ( 23382691) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Multiple myeloma ( 27363682 33875642) Red blood cell count ( 32888494)
Interacting Genes		21 interacting genes: ARHGAP1 BCL2L13 CCNE1 ESR1 ESRRA FANCA JUN MAPK14 NR1H4 NR5A1 NR5A2 PBX1 PPARG RARA RARB RARG RORA RXRA SMARCC1 SREBF1 STARD13
Entrez ID		6604
HPRD ID		03440
Ensembl ID		ENSG00000082014
Uniprot IDs		A0A090N8Z9 Q6STE5
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Transcription Coregulator Binding Intracellular Receptor Signaling Pathway RNA Polymerase II Transcription Regulator Complex Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Intracellular Signal Transduction Retinoic Acid Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Animal Organ Development Positive Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Nucleoplasm Chromatin Binding Cell Differentiation Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Developmental Process Nuclear Retinoid X Receptor Binding Signal Transduction DNA Binding Response To Lipid Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Glandular Epithelial Cell Development Transcription Cis-regulatory Region Binding DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Gland Development Regulation Of MiRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Developmental Process Positive Regulation Of Metabolic Process Negative Regulation Of Developmental Process
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