PRSS2 and SLPI

Number of citations of the paper that reports this interaction (PMID 8573092)
3

Data Source:
HPRD (in vitro)

		PRSS2	SLPI
Gene Name		protease, serine, 2 (trypsin 2)	secretory leukocyte peptidase inhibitor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding
	Biological Process	Proteolysis Digestion Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Collagen Catabolic Process Innate Immune Response Positive Regulation Of Cell Adhesion	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Binding Negative Regulation Of Viral Genome Replication
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Alpha-defensins Defensins Degradation of the extracellular matrix Innate Immune System
Drugs
Diseases
GWAS		Pancreatitis ( 23143602)
Protein-Protein Interactions		6 interactors: APP BPI CSN1S1 MMP9 SERPINA1 SLPI	10 interactors: CTSB CTSL CTSS ELANE FAM9B GRN KLK3 PLSCR1 PRSS2 SGTA
Entrez ID		5645	6590
HPRD ID		03335	00121
Ensembl ID			ENSG00000124107
Uniprot IDs		A6XMV8 A6XMV9 P07478 Q5NV56	P03973
PDB IDs			2Z7F 4DOQ
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Binding Negative Regulation Of Endopeptidase Activity Regulation Of Binding Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Platelet Degranulation Response To Methanol Regulation Of Proteolysis Response To External Stimulus Response To Triglyceride Synaptic Growth At Neuromuscular Junction Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Collateral Sprouting In Absence Of Injury Negative Regulation Of Protein Metabolic Process Response To Chromate Positive Regulation Of Receptor Binding Platelet Activation Positive Regulation Of Keratinocyte Migration Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Axon Choice Point Recognition Negative Regulation Of Macrophage Activation Neuron Remodeling Exocytosis Defense Response Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Interleukin-8 Production Axon Guidance Blood Coagulation Cellular Copper Ion Homeostasis Hemostasis Negative Regulation Of Cation Channel Activity Macrophage Differentiation Copper Ion Homeostasis Suckling Behavior Response To Bacterium Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Secretion By Cell Regulation Of Macrophage Activation Response To Lead Ion	Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Defense Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Immune Response Acute Inflammatory Response Proteolysis Regulation Of Immune Response Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Immune System Process Response To Stress Immune Response Protein Catabolic Process Regulation Of Immune System Process Regulation Of Inflammatory Response Innate Immune Response Catabolic Process Inflammatory Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response-regulating Signaling Pathway Positive Regulation Of Inflammatory Response Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Factor XII Activation Neutrophil Mediated Killing Of Fungus Basement Membrane Disassembly Macrophage Apoptotic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To Hormone Stimulus Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Response To Organic Substance Response To Stimulus Positive Regulation Of Fibrinolysis Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Response To Yeast Phosphatidylserine Biosynthetic Process
Tagcloud ?		alternating appreciated blocks border boundary colocalizes dimethylation extending extends fails h3ac h3k4me2 h3k9me2 helps initiate insulator integrity interspersed ltr opening repressive retroviral segments speculate spread tcrb thymocytes transgene trypsinogen	21x 72x a2 a2t annexin attributed correlating embedded entities facilitating formalin heterotetramer hnscc hnsccs hpv inverse lab nonsmokers paraffin protect protects putatively scc separately smokers supports surplus tobacco tonsillar
Tagcloud (Difference) ?		alternating appreciated blocks border boundary colocalizes dimethylation extending extends fails h3ac h3k4me2 h3k9me2 helps initiate insulator integrity interspersed ltr opening repressive retroviral segments speculate spread tcrb thymocytes transgene trypsinogen	21x 72x a2 a2t annexin attributed correlating embedded entities facilitating formalin heterotetramer hnscc hnsccs hpv inverse lab nonsmokers paraffin protect protects putatively scc separately smokers supports surplus tobacco tonsillar
Tagcloud (Intersection) ?