PRSS2 and CSN1S1

Number of citations of the paper that reports this interaction (PubMedID 20304780)
66

Data Source:
BioGRID (enzymatic study)

		PRSS2	CSN1S1
Description		serine protease 2	casein alpha s1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Azurophil Granule Lumen	Extracellular Region Extracellular Space
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding	Protein Binding
	Biological Process	Proteolysis Digestion Antimicrobial Humoral Response Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Collagen Catabolic Process Positive Regulation Of Cell Adhesion	Response To Estradiol Response To Progesterone Response To Dehydroepiandrosterone Response To 11-deoxycorticosterone
Pathways		Collagen degradation Alpha-defensins Activation of Matrix Metalloproteinases Neutrophil degranulation Antimicrobial peptides	Miscellaneous transport and binding events
Drugs		Monoisopropylphosphorylserine O-Benzylsulfonyl-Serine Benzylamine Benzamidine Phosphorylisopropane Phenethylamine 3-Phenylpropylamine
Diseases		Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS		Pancreatitis ( 23143602)
Interacting Genes		7 interacting genes: APP BPI CSN1S1 GLP1R MMP9 SERPINA1 SLPI	11 interacting genes: CSNK2A1 CSNK2B HTRA2 PARK7 PLK1 PPM1J PRSS2 STK4 TOLLIP TTBK1 UBQLN2
Entrez ID		5645	1446
HPRD ID		03335	00280
Ensembl ID		ENSG00000275896	ENSG00000126545
Uniprot IDs		A0A0J9YYC8 A6XMV9 P07478 Q5NV56 Q6PK75	P47710
PDB IDs
Enriched GO Terms of Interacting Partners?		Antibacterial Humoral Response Extracellular Space Antimicrobial Humoral Response Humoral Immune Response Heparan Sulfate Binding Defense Response To Bacterium Serine-type Endopeptidase Inhibitor Activity Extracellular Region Defense Response To Gram-negative Bacterium Peptidase Inhibitor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Response To Bacterium Extracellular Matrix Lipopolysaccharide Binding Extracellular Exosome Innate Immune Response Response To External Biotic Stimulus Negative Regulation Of Blood Pressure Defense Response Amyloid-beta Complex Growth Cone Lamellipodium Defense Response To Symbiont Regulation Of Response To Calcium Ion Platelet Alpha Granule Lumen Defense Response To Other Organism Regulation Of Multicellular Organism Growth Amylin Binding Response To Amyloid-beta Positive Regulation Of Toll Signaling Pathway Specific Granule Lumen Response To Lipopolysaccharide Response To Lipid Response To 11-deoxycorticosterone Zymogen Binding Glucagon-like Peptide 1 Receptor Activity Response To Molecule Of Bacterial Origin Cellular Response To Oxygen-containing Compound Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Pigment Granule Aggregation In Cell Center PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization	Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Regulation Of Protein Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Proteolysis Protein Serine/threonine Kinase Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Autophagy Identical Protein Binding PML Body Protein Serine Kinase Activity Negative Regulation Of Protein Catabolic Process Regulation Of Protein Stability Regulation Of Autophagy Negative Regulation Of Catabolic Process Phosphorylation Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Sumoylation Positive Regulation Of Apoptotic Signaling Pathway Execution Phase Of Apoptosis Protein Localization To Site Of Double-strand Break PcG Protein Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Kinase Activity Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Macroautophagy Regulation Of Cellular Response To Stress Positive Regulation Of Protein Catabolic Process Positive Regulation Of Catabolic Process Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Peptidyl-serine Phosphorylation Macromolecule Metabolic Process Wnt Signaling Pathway Protein Localization To Organelle Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Growth Negative Regulation Of DNA Recombination Protein Stabilization Kinase Activity
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