PRSS2 and CSN1S1

Number of citations of the paper that reports this interaction (PMID 20304780)
17

Data Source:
BioGRID (enzymatic study)

		PRSS2	CSN1S1
Gene Name		protease, serine, 2 (trypsin 2)	casein alpha s1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Extracellular Region Extracellular Space
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Transporter Activity
	Biological Process	Proteolysis Digestion Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Collagen Catabolic Process Innate Immune Response Positive Regulation Of Cell Adhesion	Transport
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Alpha-defensins Defensins Degradation of the extracellular matrix Innate Immune System
Drugs
Diseases
GWAS		Pancreatitis ( 23143602)
Protein-Protein Interactions		6 interactors: APP BPI CSN1S1 MMP9 SERPINA1 SLPI	11 interactors: CSNK2A1 CSNK2B HTRA2 PARK7 PLK1 PPM1J PRSS2 SAP130 STK4 TOLLIP TTBK1
Entrez ID		5645	1446
HPRD ID		03335	00280
Ensembl ID			ENSG00000126545
Uniprot IDs		A6XMV8 A6XMV9 P07478 Q5NV56	P47710
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Binding Negative Regulation Of Endopeptidase Activity Regulation Of Binding Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Platelet Degranulation Response To Methanol Regulation Of Proteolysis Response To External Stimulus Response To Triglyceride Synaptic Growth At Neuromuscular Junction Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Collateral Sprouting In Absence Of Injury Negative Regulation Of Protein Metabolic Process Response To Chromate Positive Regulation Of Receptor Binding Platelet Activation Positive Regulation Of Keratinocyte Migration Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Axon Choice Point Recognition Negative Regulation Of Macrophage Activation Neuron Remodeling Exocytosis Defense Response Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Interleukin-8 Production Axon Guidance Blood Coagulation Cellular Copper Ion Homeostasis Hemostasis Negative Regulation Of Cation Channel Activity Macrophage Differentiation Copper Ion Homeostasis Suckling Behavior Response To Bacterium Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Secretion By Cell Regulation Of Macrophage Activation Response To Lead Ion	Positive Regulation Of Protein Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Binding Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Peptidyl-serine Phosphorylation Positive Regulation Of Protein Modification Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Binding Regulation Of Protein Sumoylation Peptidyl-amino Acid Modification Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Toxic Substance Negative Regulation Of Oxidative Stress-induced Cell Death Phosphorylation Phosphate-containing Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Growth Positive Regulation Of Signal Transduction Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Proteolysis Protein Phosphorylation Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Cell Death Positive Regulation Of Protein Binding Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		alternating appreciated blocks border boundary colocalizes dimethylation extending extends fails h3ac h3k4me2 h3k9me2 helps initiate insulator integrity interspersed ltr opening repressive retroviral segments speculate spread tcrb thymocytes transgene trypsinogen	0x 1x 25x 2x 4ebp1 4x 5x 8x arg arginine bovine casein conditionally csn2 csn3 devoid except excess experimental gland mammary mtor output resemble s6k stat5 true
Tagcloud (Difference) ?		alternating appreciated blocks border boundary colocalizes dimethylation extending extends fails h3ac h3k4me2 h3k9me2 helps initiate insulator integrity interspersed ltr opening repressive retroviral segments speculate spread tcrb thymocytes transgene trypsinogen	0x 1x 25x 2x 4ebp1 4x 5x 8x arg arginine bovine casein conditionally csn2 csn3 devoid except excess experimental gland mammary mtor output resemble s6k stat5 true
Tagcloud (Intersection) ?