AGO3 and BDNF

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		AGO3	BDNF
Gene Name		argonaute RISC catalytic component 3	brain-derived neurotrophic factor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Cytosol Membrane RISC Complex Micro-ribonucleoprotein Complex	Extracellular Region Extracellular Space Cytoplasm Synaptic Vesicle Cytoplasmic Membrane-bounded Vesicle Mitochondrial Crista Dendrite Terminal Bouton Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding MiRNA Binding Poly(A) RNA Binding	Neurotrophin TRKB Receptor Binding Growth Factor Activity
	Biological Process	MRNA Catabolic Process Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Posttranscriptional Gene Silencing Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Stem Cell Proliferation	Ureteric Bud Development Behavioral Fear Response Response To Hypoxia Chronic Inflammatory Response Mitochondrial Electron Transport, NADH To Ubiquinone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Nervous System Development Negative Regulation Of Neuroblast Proliferation Axon Guidance Axon Target Recognition Learning Circadian Rhythm Feeding Behavior Neuron Recognition Response To Light Intensity Response To Hormone Response To Auditory Stimulus Glutamate Secretion Response To Fluoxetine Response To Activity Dendrite Development Nerve Development Regulation Of Axon Extension Response To Food Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Peptidyl-serine Phosphorylation Response To Vitamin A Response To Potassium Ion Mechanoreceptor Differentiation Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Striated Muscle Tissue Development Regulation Of Retinal Cell Programmed Cell Death Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Axon Extension Neuron Projection Morphogenesis Inner Ear Development Response To Electrical Stimulus Positive Regulation Of Synapse Assembly Response To Hyperoxia Regulation Of Excitatory Postsynaptic Membrane Potential Taste Bud Development Cellular Response To Tumor Necrosis Factor Cellular Response To Norepinephrine Stimulus Response To Anesthetic Dendrite Extension Response To L-glutamate Cellular Response To Nerve Growth Factor Stimulus
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Regulatory RNA pathways Cellular Senescence Signaling by Wnt Signaling by EGFRvIII in Cancer Oncogene Induced Senescence Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Pre-NOTCH Transcription and Translation PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Pre-NOTCH Expression and Processing Post-transcriptional silencing by small RNAs Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by NOTCH Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 MicroRNA (miRNA) biogenesis Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR beta-catenin independent WNT signaling Signaling by ERBB2 Signaling by EGFR Ca2+ pathway Oxidative Stress Induced Senescence Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Small interfering RNA (siRNA) biogenesis Adaptive Immune System
Drugs
Diseases
GWAS			Body mass index ( 22344221 23563607 19079260 20935630) Obesity ( 21708048 23563607) Smoking behavior ( 20418890) Weight ( 19079260)
Protein-Protein Interactions		4 interactors: ATP4B ATP6V0D2 BDNF SLC22A2	14 interactors: AGO3 APP CADPS2 CPE ESR1 F11R INPP5K JUNB MBTPS1 NCAM1 NOS3 NTF3 NTRK2 SORT1
Entrez ID		192669	627
HPRD ID		09558	00214
Ensembl ID		ENSG00000126070	ENSG00000176697
Uniprot IDs		B4E1P5 Q9H9G7	P23560
PDB IDs			1B8M 1BND
Enriched GO Terms of Interacting Partners?		Ion Transport Monovalent Inorganic Cation Transport Response To Anesthetic Response To Fluoxetine Response To L-glutamate Response To Organonitrogen Compound Cation Transmembrane Transport Hydrogen Ion Transmembrane Transport Taste Bud Development Regulation Of Retinal Cell Programmed Cell Death Dendrite Extension Cellular Response To Norepinephrine Stimulus Cation Transport Proton Transport Ion Transmembrane Transport Axon Target Recognition Response To Norepinephrine Response To Ether Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Synaptic Transmission, GABAergic Choline Transport Response To Potassium Ion Transmembrane Transport Transport Regulation Of Short-term Neuronal Synaptic Plasticity Response To Light Intensity Chronic Inflammatory Response Cellular Response To Organonitrogen Compound Neurotransmitter Biosynthetic Process Secretion By Cell Response To Drug Histamine Transport Quaternary Ammonium Group Transport Response To Auditory Stimulus Synaptic Transmission Response To Food Glutamate Secretion Secretion Cellular Response To Catecholamine Stimulus Response To Organic Substance Anion Transport Cellular Response To Nerve Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Vitamin A Negative Regulation Of Neuroblast Proliferation Neurotransmitter Metabolic Process Gamma-aminobutyric Acid Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Transferrin Transport Drug Transmembrane Transport	Signaling Cell Surface Receptor Signaling Pathway Cell Communication Cellular Response To Organic Substance Cellular Response To Stimulus Signal Transduction Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Catalytic Activity Anatomical Structure Development Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Biosynthetic Process Developmental Process Anatomical Structure Morphogenesis Cell Differentiation Positive Regulation Of Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cell Development Response To External Stimulus Locomotion Multicellular Organismal Development Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Response To Radiation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Gene Expression Regulation Of Cellular Ketone Metabolic Process Cellular Localization Positive Regulation Of Hydrolase Activity Regulation Of Nitric-oxide Synthase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization Regulation Of Protein Phosphorylation Response To Stress Negative Regulation Of Calcium Ion Transport Neurotrophin Signaling Pathway Response To Abiotic Stimulus
Tagcloud ?		aberrant ago4 biogenesis cancerous carcinogenesis cigarette combinations components deregulation dgcr8 dicer encodes etiological hbv hcc hepatocarcinogenesis hepatocellular implicated integrated mirna multicentric occurrence p68 p72 paired piwil4 prognosis promoters trimethylation	accumulated altering believed ca2 causally cerebellar correlates dependency downregulating downregulation elicited evoked excitotoxic excitotoxicity fgf2 fibroblast fura granule neurotrophic nmda nr1 nr2a nr2c prevent protect rnase trauma trophic vulnerable
Tagcloud (Difference) ?		aberrant ago4 biogenesis cancerous carcinogenesis cigarette combinations components deregulation dgcr8 dicer encodes etiological hbv hcc hepatocarcinogenesis hepatocellular implicated integrated mirna multicentric occurrence p68 p72 paired piwil4 prognosis promoters trimethylation	accumulated altering believed ca2 causally cerebellar correlates dependency downregulating downregulation elicited evoked excitotoxic excitotoxicity fgf2 fibroblast fura granule neurotrophic nmda nr1 nr2a nr2c prevent protect rnase trauma trophic vulnerable
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