AGO3 and SLC22A2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		AGO3	SLC22A2
Description		argonaute RISC catalytic component 3	solute carrier family 22 member 2
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome P-body Nucleus Nucleoplasm Cytoplasm Cytosol Membrane RISC Complex Cytoplasmic Ribonucleoprotein Granule RISC-loading Complex Ribonucleoprotein Complex	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extracellular Exosome Presynapse
	Molecular Function	Nucleic Acid Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Hydrolase Activity MiRNA Binding Metal Ion Binding Endoribonuclease Activity, Cleaving MiRNA-paired MRNA	Amine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Organic Anion Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Choline Transmembrane Transporter Activity Thiamine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity
	Biological Process	MRNA Catabolic Process Regulation Of Translation Positive Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA Processing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization RISC Complex Assembly Regulation Of Stem Cell Proliferation SiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Monoatomic Ion Transport Monoatomic Cation Transport Neurotransmitter Transport Serotonin Transport Body Fluid Secretion Organic Cation Transport Quaternary Ammonium Group Transport Prostaglandin Transport Amine Transport Putrescine Transport Spermidine Transport Acetylcholine Transport Choline Transport Dopamine Transport Norepinephrine Transport Xenobiotic Transport Epinephrine Transport Histamine Transport Serotonin Uptake Histamine Uptake Norepinephrine Uptake Transmembrane Transport Thiamine Transmembrane Transport Purine-containing Compound Transmembrane Transport Amino Acid Import Across Plasma Membrane Dopamine Uptake L-arginine Import Across Plasma Membrane Export Across Plasma Membrane Transport Across Blood-brain Barrier L-alpha-amino Acid Transmembrane Transport Spermidine Transmembrane Transport L-arginine Transmembrane Transport Cellular Detoxification Xenobiotic Transport Across Blood-brain Barrier
Pathways		Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Small interfering RNA (siRNA) biogenesis Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Nuclear events stimulated by ALK signaling in cancer Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH11 mRNA translation by microRNAs Regulation of CDH1 mRNA translation by microRNAs Regulation of NPAS4 mRNA translation Regulation of MITF-M-dependent genes involved in apoptosis TGFBR3 expression Regulation of PD-L1(CD274) translation	Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport SLC-mediated transport of neurotransmitters SLC-mediated transport of organic cations
Drugs
Diseases
GWAS			A body shape index ( 34021172) Body mass index ( 25673413 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronic kidney disease ( 20383146 31152163) Creatinine levels ( 31015462 29403010 20383145) Estimated glomerular filtration rate ( 31451708 31152163 31015462 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Familial squamous cell lung carcinoma ( 29924316) Glomerular filtration rate ( 29403010 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Hip circumference adjusted for BMI ( 34021172) Kidney stones ( 31729369) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284) Prostate cancer ( 26034056) Serum metabolite levels ( 23093944) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference ( 26785701) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: ATP4B ATP6V0D2 BDNF CFTR SLC22A2	45 interacting genes: AGO3 CCL2 CD63 CD9 CLPTM1 CST9L CYB5R3 DPM2 EEF1G ETV5 FAIM2 FIS1 FXYD2 FZD5 GTF2B HNRNPH3 HRCT1 HYAL3 ITM2C KRTCAP2 LAPTM4A LAPTM4B LAPTM5 LSM4 NCOA3 PDIA6 PDZK1IP1 POU2AF1 PRPF8 RPN2 SERP1 SLC40A1 SLC47A2 SNCA SPCS1 STX8 SUMO2 TMEM134 TMEM147 TMEM161A TMEM176B TMEM41B TMX2 TREX1 VKORC1
Entrez ID		192669	6582
HPRD ID		09558	04008
Ensembl ID		ENSG00000126070	ENSG00000112499
Uniprot IDs		B4E1P5 Q9H9G7	O15244
PDB IDs		5VM9 8VAJ	8ET9
Enriched GO Terms of Interacting Partners?		Regulation Of PH Apical Plasma Membrane Intracellular Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Transmembrane Transport Export Across Plasma Membrane Monoatomic Ion Transport Intracellular Monoatomic Cation Homeostasis Early Endosome Regulation Of Cellular PH Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Intracellular PH C-X-C Motif Chemokine 12 Receptor Activity Monoatomic Ion Homeostasis Cellular Homeostasis Import Across Plasma Membrane Inorganic Ion Transmembrane Transport P-type Potassium:proton Transporter Activity Potassium:proton Exchanging ATPase Complex Intracellular Chemical Homeostasis Proton Transmembrane Transport Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Organic Hydroxy Compound Transport Positive Regulation Of Monoatomic Anion Transport Acetylcholine Transport Histamine Uptake Pyrimidine Nucleoside Transmembrane Transporter Activity Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Amine Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Plasma Membrane Proton-transporting V-type ATPase Complex Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Nerve Growth Factor Receptor Binding Endosome Transepithelial Water Transport Spermidine Transport Thiamine Transmembrane Transporter Activity	Membrane Endoplasmic Reticulum Oligosaccharyltransferase Complex Regulation Of Lysosomal Membrane Permeability Endoplasmic Reticulum Membrane Multivesicular Body, Internal Vesicle Response To Peptide
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?