PRSS8 and HNRNPLL

Data Source: HiPPIP (Novel)

		PRSS8	HNRNPLL
Name		serine protease 8	heterogeneous nuclear ribonucleoprotein L like
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome	Nucleus Membrane Synapse Ribonucleoprotein Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Proteolysis Positive Regulation Of Sodium Ion Transport	MRNA Processing Positive Regulation Of RNA Splicing Regulation Of RNA Splicing
Pathways		Formation of the cornified envelope	None
Drugs		1-[4-(hydroxymethyl)phenyl]guanidine	None
GWAS		Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 )	Body mass index ( 28892062 )
Novel Interactors		1 novel interactors: HNRNPLL	10 novel interactors: DHX57 GTF2A1 MAP4K3 NRG2 OTOF PRSS8 SRSF7 TMEM178A TRIM29 ZNF311
Interacting Genes		2 interacting genes: ATF7IP SLC13A1	57 interacting genes: ADAMTSL4 ATXN1 BANP BARD1 BCAS2 BHLHE40 BOLL CALCOCO2 CEBPA DAB1 DDX39A DDX39B DENND2D EFHC2 EIF4ENIF1 FAM9B GOPC HNRNPK HOOK1 IKZF3 KHDRBS2 KRT31 KRT40 KRTAP10-3 MAGED1 MDFI MID2 MREG PAXIP1 PCBP1 PCBP3 PNMA1 POLR1F PRPF6 PTBP1 QKI RBM10 RBM3 RBPMS REL RHOXF2 SKIL SNRPA SPRY2 SRSF11 SSX2IP SUMO2 TADA2A THAP1 TLE5 TMCC2 TRIM23 TRIM27 UBE2I USP10 VAC14 WEE2-AS1
Entrez ID		5652	92906
HPRD ID		02895	13667
Ensembl ID		ENSG00000052344	ENSG00000143889
Uniprot IDs		Q16651	A0A0S2Z6K1 A8K894 Q8WVV9
PDB IDs		3DFJ 3DFL 3E0N 3E0P 3E16 3E1X 3FVF 3GYL 3GYM	7EVS
GO Terms Enriched among Interactors		Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Secondary Active Sulfate Transmembrane Transporter Activity	Nucleic Acid Binding Identical Protein Binding RNA Binding Regulation Of MRNA Processing MRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Processing RNA Splicing Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process PML Body MRNA Metabolic Process Nucleus Regulation Of RNA Splicing Regulation Of Transcription By RNA Polymerase II Nuclear Speck RNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Splicing Nucleic Acid Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Response To Cytokine Response To Peptide Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process SUMO Transferase Activity Regulation Of Metabolic Process Spliceosomal Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process MRNA Stabilization Nuclear Export Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process