SLC12A3

Gene Name		solute carrier family 12 (sodium/chloride transporter), member 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Transporter Activity Protein Binding Sodium:chloride Symporter Activity
	Biological Process	Transport Ion Transport Sodium Ion Transport Chloride Transport Sodium Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport
Pathways		Transport of inorganic cations/anions and amino acids/oligopeptides Cation-coupled Chloride cotransporters SLC-mediated transmembrane transport
Drugs		Bendroflumethiazide Metolazone Benzthiazide Chlorothiazide Hydrochlorothiazide Diazoxide Polythiazide Quinethazone
Diseases
GWAS		HDL cholesterol ( 20031564 23505323)
Protein-protein Interactions		2 interactors: PDIA3 WNK4
Entrez ID		6559
HPRD ID		02984
Ensembl ID		ENSG00000070915
Uniprot IDs		J3QSS1 P55017
PDB IDs
Enriched GO Terms of Interacting Partners?		Distal Tubule Morphogenesis Renal Sodium Ion Absorption Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport Protein Retention In ER Lumen Maintenance Of Protein Localization In Endoplasmic Reticulum Renal Absorption Distal Tubule Development Homeostatic Process Protein Localization Nephron Morphogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Renal Tubule Morphogenesis Renal System Process Renal Tubule Development Protein N-linked Glycosylation Via Asparagine Kidney Morphogenesis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Protein N-linked Glycosylation Protein Import Into Nucleus Cell Redox Homeostasis Nuclear Import Protein Localization To Endoplasmic Reticulum Chloride Transport Maintenance Of Protein Location In Cell Nephron Development Maintenance Of Protein Location Maintenance Of Location In Cell Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Import Kidney Epithelium Development Response To Endoplasmic Reticulum Stress Protein Localization To Nucleus Negative Regulation Of Secretion Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Post-translational Protein Modification
Tagcloud ?		adaptations adjustments alpha1beta1 arystarkhova ascending atpase compensatory convoluted cotransporter dct fxyd fxyd2 generates hypoplasia na ncc nephron nkcc2 nonetheless permissive reabsorption s71 segment t53 thiazide thick tubule twofold