PYCR3 and LBP

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		PYCR3	LBP
Name		pyrroline-5-carboxylate reductase 3	lipopolysaccharide binding protein
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Intercellular Bridge Mitotic Spindle	Extracellular Region Extracellular Space Cell Surface Membrane Extracellular Exosome
	Molecular Function	Pyrroline-5-carboxylate Reductase Activity Protein Binding Oxidoreductase Activity Identical Protein Binding	Lipopolysaccharide Binding Signaling Receptor Binding Protein Binding Lipid Binding Coreceptor Activity Lipoteichoic Acid Binding Lipopeptide Binding
	Biological Process	Amino Acid Biosynthetic Process L-proline Biosynthetic Process	Leukocyte Chemotaxis Involved In Inflammatory Response Macrophage Activation Involved In Immune Response Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Lipid Transport Acute-phase Response Cellular Defense Response Opsonization Lipopolysaccharide Transport Neutrophil Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Detection Of Molecule Of Bacterial Origin Response To Lipopolysaccharide Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Defense Response To Bacterium Positive Regulation Of Macrophage Activation Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis
Pathways		Glutamate and glutamine metabolism	Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling
Drugs		Proline	None
GWAS		No GWAS studies recorded	Basophil percentage of white cells ( 32888494 ) Periodontitis (DPAL) ( 24024966 )
Interacting Genes		11 interacting genes: AKT1 BAG4 CDKN2B FXR1 FXR2 HOXA1 LBP NTAQ1 PRMT6 PSMB1 SDCBP	18 interacting genes: APOA1 BAG6 BST1 C4BPA CAMP CBFA2T2 CD14 CFHR1 FTH1 HSPB1 PRDX4 PSMA3 PYCR3 RPS21 SETD1A SMAD3 TRA2A TSC22D4
Entrez ID		65263	3929
HPRD ID		15196	07175
Ensembl ID		ENSG00000104524	ENSG00000129988
Uniprot IDs		A0A0A0MQS1 B4DGI7 Q53H96	P18428 Q8TCF0
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of MRNA Metabolic Process Positive Regulation Of Fibroblast Migration Translation Regulator Activity Positive Regulation Of Translation Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of MRNA Stability Localization Within Membrane Postsynapse Regulation Of Fibroblast Migration Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of RNA Stability Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cell Communication Nucleus Regulation Of Signaling Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Locomotion Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Metabolic Process Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of TRNA Methylation Response To Epidermal Growth Factor Semicircular Canal Formation Interleukin-5 Receptor Complex Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of MRNA Modification Protein-N-terminal Glutamine Amidohydrolase Activity Histone H2AR3 Methyltransferase Activity Cellular Senescence Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Multicellular Organismal Process Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Protein Localization To Lysosome Translational Initiation Regulation Of Behavior Abducens Nerve Formation	Regulation Of Interleukin-1 Production Regulation Of Interleukin-1 Beta Production Immune Response Immune System Process Positive Regulation Of Interleukin-1 Production Cytolysis By Host Of Symbiont Cells Positive Regulation Of Interleukin-1 Beta Production Extracellular Region Extracellular Exosome Regulation Of Immune System Process Humoral Immune Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Adrenal Gland Development Blood Microparticle Identical Protein Binding Regulation Of Immune Response Killing By Host Of Symbiont Cells Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Response To Other Organism Response To Stress Activation Of Immune Response Lipopolysaccharide Binding Regulation Of Tumor Necrosis Factor Production Prostaglandin Production Involved In Inflammatory Response Biological Process Involved In Interaction With Symbiont Opsonin Receptor Activity Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Humoral Immune Response Positive Regulation Of Stress Fiber Assembly Regulation Of Chemotaxis Tertiary Granule Lumen Regulation Of Cytokine Production Regulation Of Defense Response Protein Stabilization Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Cell-substrate Adhesion Complement Activation Positive Regulation Of Cytokine Production Cellular Response To Butyrate Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Interleukin-8 Production Ferritin Complex Iron Ion Sequestering Activity Proteasome Complex