RAPH1 and DNMBP

Number of citations of the paper that reports this interaction (PubMedID 14506234)
0

Data Source:
HPRD (in vitro)

		RAPH1	DNMBP
Description		Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	dynamin binding protein
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Nuclear Body Lamellipodium Filopodium Cell Leading Edge Cell Projection	Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Golgi Stack Cytosol Cytoskeleton Cell-cell Junction Nuclear Body Synapse Anchoring Junction Presynapse
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Signal Transduction Axon Extension	Regulation Of Cell Shape Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Cilium Assembly
Pathways			CDC42 GTPase cycle
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Bone mineral density (total hip) ( 29883787) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Systemic lupus erythematosus ( 28714469)	Stent thrombosis in response to clopidogrel treatment ( 32472697)
Interacting Genes		5 interacting genes: CLK1 DNMBP MYO10 SIAH1 VASP	21 interacting genes: ACTA1 ARHGAP17 BUB1B CDC42 CNN1 CYFIP2 DBN1 DNM1 ENAH EVL FASLG HSPA1B KHDRBS1 NCKAP1 RAC1 RAPH1 UBC VASP WASF1 WASL WIPF2
Entrez ID		65059	23268
HPRD ID		12356	10918
Ensembl ID		ENSG00000173166	ENSG00000107554
Uniprot IDs		C9K0J5 Q70E73	A0A1B0GTX1 A0A1C7CYY6 B3KY33 Q6XZF7
PDB IDs		4GMV 4GN1	1UG1 1UHC 4CC2 4CC3 4CC4 4CC7 4GLM
Enriched GO Terms of Interacting Partners?		Filopodium Membrane Filopodium	Actin Filament Organization Lamellipodium Cytoskeleton Actin Polymerization Or Depolymerization Supramolecular Fiber Organization Profilin Binding Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Actin Binding Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Filopodium Neuron Projection Development Positive Regulation Of Protein Polymerization Actin Cytoskeleton Organization SH3 Domain Binding Positive Regulation Of Cellular Component Organization Postsynapse SCAR Complex Positive Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Polymerization Actin Filament-based Process Plasma Membrane Bounded Cell Projection Organization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Regulation Of Postsynapse Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Cellular Component Organization Regulation Of Actin Filament Length Actin Cytoskeleton Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Cell Projection Organization Cytoplasm Rac Protein Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Cytosol Positive Regulation Of Lamellipodium Assembly Axon Guidance Neuron Projection Guidance Cell Projection Regulation Of Cell Projection Assembly Actin Filament Polymerization Extracellular Exosome Positive Regulation Of Lamellipodium Organization
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