GALNT13 and EXOSC2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		GALNT13	EXOSC2
Description		polypeptide N-acetylgalactosaminyltransferase 13	exosome component 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex)
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Carbohydrate Binding Metal Ion Binding	3'-5'-RNA Exonuclease Activity RNA Binding RNA Exonuclease Activity Protein Binding 7S RNA Binding
	Biological Process	Protein Glycosylation Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing RNA Processing RNA Catabolic Process Positive Regulation Of Cell Growth U4 SnRNA 3'-end Processing CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Poly(A)-dependent SnoRNA 3'-end Processing
Pathways		O-linked glycosylation of mucins	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Aging traits ( 17903295) Blood trace element (Zn levels) ( 23720494) Body mass index ( 24348519) Coronary artery disease in type 1 diabetes ( 29695241) Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) Liver enzyme levels (alanine transaminase) ( 24124411) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Obesity-related traits ( 23251661) Placental abruption ( 29884306) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Schizophrenia or schizoaffective disorder ( 31591465) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		2 interacting genes: EXOSC2 SKIC2	18 interacting genes: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MRPL48 MTREX PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 ZNF408
Entrez ID		114805	23404
HPRD ID		16325	03758
Ensembl ID		ENSG00000144278	ENSG00000130713
Uniprot IDs		A0A1L4BJA8 B3KY85 Q8IUC8	B3KQW2 Q13868
PDB IDs			2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress MRNA Catabolic Process Ski Complex Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Nucleobase-containing Compound Catabolic Process 3'-5' RNA Helicase Activity Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) 7S RNA Binding TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process U4 SnRNA 3'-end Processing Poly(A)-dependent SnoRNA 3'-end Processing RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Voltage-gated Sodium Channel Complex TRNA Decay Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Voltage-gated Sodium Channel Activity Sno(s)RNA Metabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Node Of Ranvier MRNA Metabolic Process SnRNA 3'-end Processing Neuronal Action Potential 3'-5'-RNA Exonuclease Activity Sodium Channel Activity Monoatomic Cation Channel Activity Rescue Of Stalled Ribosome SnRNA Processing Nuclear RNA Surveillance Cardiac Muscle Cell Action Potential Involved In Contraction Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Surveillance Cardiac Muscle Cell Action Potential Ribosome Disassembly Cellular Response To Osmotic Stress SnRNA Metabolic Process Macromolecule Catabolic Process Translational Elongation Response To Osmotic Stress Negative Regulation Of Gene Expression RNA Helicase Activity Organelle Disassembly RNA 3'-end Processing	Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RRNA Catabolic Process U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Exoribonuclease Complex Nuclear RNA Surveillance RNA Surveillance SnRNA 3'-end Processing SnRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process SnRNA Processing RNA Catabolic Process MRNA Catabolic Process MRNA 3'-UTR AU-rich Region Binding 3'-5'-RNA Exonuclease Activity RRNA Processing Nucleobase-containing Compound Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing RNA 3'-end Processing RRNA Metabolic Process MRNA Metabolic Process Macromolecule Catabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay DNA Deamination Sno(s)RNA Metabolic Process RNA Processing DNA Modification Nucleolus RNA Binding Catabolic Process RNA Metabolic Process Negative Regulation Of Gene Expression Macromolecule Metabolic Process Nucleic Acid Metabolic Process Histone MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Maturation Of 5.8S RRNA Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process
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