MORC4 and GEMIN4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MORC4	GEMIN4
Description		MORC family CW-type zinc finger 4	gem nuclear organelle associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Body Small Nuclear Ribonucleoprotein Complex SMN Complex SMN-Sm Protein Complex Extracellular Exosome Gemini Of Cajal Bodies
	Molecular Function	Protein Binding Zinc Ion Binding ATP Hydrolysis Activity Metal Ion Binding Histone H3K4me3 Reader Activity	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Chromatin Organization	Spliceosomal SnRNP Assembly RRNA Processing MRNA Processing RNA Splicing
Pathways			snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Pancreatitis ( 23143602)	Prostate cancer ( 23535732)
Interacting Genes		4 interacting genes: GEMIN4 PRKAA1 SKIL STAT3	57 interacting genes: AGO2 ALPP CALCOCO2 CCDC185 CCT3 CDC20B CERCAM CFP DDX20 DHX9 DMPK FBXL12 FLAD1 GEMIN5 GLYR1 HR KANK2 KARS1 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP2-3 KRTAP2-4 KRTAP9-2 LGALS1 LGALS3 LY86 MORC4 NPPB NUFIP1 PIAS3 PSMB1 PTCD1 PTEN RAD51D RN7SL1 RNASE2 RNF10 RNU1-1 RNU2-1 S1PR4 SNRPB SNRPD1 SNRPD2 SPG21 SPRY1 SQSTM1 SRRT STXBP2 STXBP3 TAP1 TOP1 UFC1 USP15 USP2 ZNF326 ZNF35
Entrez ID		79710	50628
HPRD ID		06757	07370
Ensembl ID		ENSG00000133131	ENSG00000179409
Uniprot IDs		B4DTP6 Q8TE76	I3L2C7 P57678 Q8WUM5 Q9HC39
PDB IDs		7K7T
Enriched GO Terms of Interacting Partners?		Regulation Of Glycolytic Process Positive Regulation Of ATP Metabolic Process Regulation Of Carbohydrate Catabolic Process Multicellular Organismal-level Homeostasis Energy Homeostasis Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Glucosylceramide Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway Response To Ethanol Protein-containing Complex Regulation Of Generation Of Precursor Metabolites And Energy Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of Small Molecule Metabolic Process Cold Acclimation Positive Regulation Of Mitochondrial Transcription Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Carbohydrate Homeostasis Glucose Homeostasis Positive Regulation Of Cellular Component Organization Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Sphingolipid Biosynthetic Process CAMP-dependent Protein Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Intracellular Signal Transduction AMP-activated Protein Kinase Activity Protein Localization To Lipid Droplet Response To Alcohol CAMKK-AMPK Signaling Cascade Transcription Regulator Complex RNA Sequestering Activity Negative Regulation Of Hydrogen Peroxide Metabolic Process Postsynapse To Nucleus Signaling Pathway Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway T-helper 17 Type Immune Response Phosphatidylethanolamine Biosynthetic Process Positive Regulation Of Phosphate Metabolic Process Protein-containing Complex Binding Response To Oxygen Levels Homeostatic Process Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Cellular Response To Hormone Stimulus	SMN-Sm Protein Complex Protein-RNA Complex Assembly Spliceosomal SnRNP Assembly U2 SnRNP 7-methylguanosine Cap Hypermethylation RNA Processing U4 SnRNP Methylosome Intermediate Filament Small Nuclear Ribonucleoprotein Complex RNA Splicing U1 SnRNP Tertiary Granule U5 SnRNP Presynaptic Dense Core Vesicle Exocytosis U2-type Prespliceosome Assembly U12-type Spliceosomal Complex MRNA Processing Perichromatin Fibrils U2-type Spliceosomal Complex RNA Polymerase II Complex Binding U2-type Catalytic Step 2 Spliceosome RNA Metabolic Process Positive Regulation Of Dendritic Cell Differentiation PICln-Sm Protein Complex Neuronal Dense Core Vesicle Exocytosis U1 SnRNP Binding Neutrophil Degranulation Transcription Elongation-coupled Chromatin Remodeling Keratin Filament RISC-loading Complex Dense Core Granule Exocytosis U4/U6 X U5 Tri-snRNP Complex RNA Binding Anaphase-promoting Complex Binding Calcium Ion-regulated Exocytosis Of Neurotransmitter RISC Complex Assembly MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly SiRNA Binding SMN Complex U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions Cytosol Locomotor Rhythm Ubiquitin Ligase Activator Activity Gemini Of Cajal Bodies Protein Binding Ribonucleoside Triphosphate Phosphatase Activity MRNA Metabolic Process
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