PSMC2 and RPN1

Number of citations of the paper that reports this interaction (PubMedID 35235311)
31

Data Source:
BioGRID (cross-linking study, pull down)

		PSMC2	RPN1
Description		proteasome 26S subunit, ATPase 2	ribophorin I
Image
GO Annotations	Cellular Component	Proteasome Complex P-body Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Membrane Proteasome Accessory Complex Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Ficolin-1-rich Granule Lumen	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Cytosol Oligosaccharyltransferase Complex Membrane Melanosome Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex B
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Proteasome-activating Activity	RNA Binding Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding
	Biological Process	Osteoblast Differentiation Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process	Protein Glycosylation Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Eosinophil count ( 27863252 29403010) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mild to moderate chronic kidney disease ( 31178898) Monocyte count ( 23314186 32888494 29403010 27863252) Monocyte percentage of white cells ( 27863252 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Neutrophil count ( 32888494) Platelet distribution width ( 32888494) Serum metabolite levels ( 33031748) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 21738480 32888494) White blood cell count (basophil) ( 29403010)
Interacting Genes		23 interacting genes: CDKN1A CEP55 CNOT7 FILNC1 GTF2B GTF2F1 GTF2H1 NDC80 NDRG1 OGT POLR2M PRKN PSMC1 PSMC4 PSMD2 PSMD5 RPN1 SKIL STUB1 SUMO4 TBP TRAF6 TRIM5	18 interacting genes: ADRM1 DPF1 DUX4 ERBB3 HSPA5 KRTAP1-3 PSMC2 RAD23A RBBP4 RBFOX2 SGTA SIGIRR SMARCB1 UBC UBQLN1 UBQLN2 UBQLN4 WSB2
Entrez ID		5701	6184
HPRD ID		01105	01598
Ensembl ID		ENSG00000161057	ENSG00000163902
Uniprot IDs		A0A140VK70 B7Z571 P35998	P04843
PDB IDs		5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 8USD 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q	6S7O 6S7T 8B6L 8PN9
Enriched GO Terms of Interacting Partners?		Proteasome Regulatory Particle, Base Subcomplex Proteasome Accessory Complex Transcription Initiation At RNA Polymerase II Promoter Proteasome Complex DNA-templated Transcription Initiation Protein K63-linked Ubiquitination Nucleus Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Transcription Factor TFIID Complex Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase II General Transcription Initiation Factor Activity Proteasome-activating Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process RNA Polymerase II General Transcription Initiation Factor Binding Protein-containing Complex Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Regulation Of Phosphorus Metabolic Process Protein Autoubiquitination Proteasome Regulatory Particle Transcription Preinitiation Complex Regulation Of Protein Ubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Ubiquitin-ubiquitin Ligase Activity Regulation Of Phosphorylation DNA-templated Transcription Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Post-translational Protein Modification Positive Regulation Of Macromolecule Metabolic Process Regulation Of Kinase Activity Positive Regulation Of DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Organelle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Ubiquitination Proteasomal Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Mitophagy Regulation Of Primary Metabolic Process Membraneless Organelle Assembly Macromolecule Biosynthetic Process Protein Polyubiquitination DNA Damage Response Positive Regulation Of Autophagy Of Mitochondrion	Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome Complex Regulation Of Cellular Response To Stress Positive Regulation Of ERAD Pathway Proteolysis Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of ERAD Pathway Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of G0 To G1 Transition Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Protein Metabolic Process Autophagosome Regulation Of Metabolic Process Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Protein-containing Complex NBAF Complex Autophagosome Assembly Proteasome Binding Cytosol Autophagosome Organization Nucleoplasm Autophagy Regulation Of Primary Metabolic Process Regulation Of Nucleotide-excision Repair Regulation Of Double-strand Break Repair Nucleosomal DNA Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Vacuole Organization Negative Regulation Of Transport
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?