EYA4 and SIX1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, proximity labelling technology)
HPRD (two hybrid, in vivo)

		EYA4	SIX1
Description		EYA transcriptional coactivator and phosphatase 4	SIX homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Repair Chromatin Organization DNA Damage Response Visual Perception Anatomical Structure Morphogenesis Cell Differentiation Positive Regulation Of DNA Repair Inner Ear Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Kidney Development Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Notch Signaling Pathway Pattern Specification Process Skeletal Muscle Tissue Development Sensory Perception Of Sound Regulation Of Synaptic Assembly At Neuromuscular Junction Gene Expression Regulation Of Gene Expression Neural Crest Cell Differentiation Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Skeletal Muscle Cell Proliferation Facial Nerve Morphogenesis Neurogenesis Epithelial Cell Differentiation Thyroid Gland Development Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Aorta Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Tongue Development Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Neuron Fate Specification Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Skeletal Muscle Fiber Development Inner Ear Development Regulation Of Epithelial Cell Proliferation Myoblast Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Otic Vesicle Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Mesonephric Tubule Formation Ureter Smooth Muscle Cell Differentiation Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Endothelin Receptor Signaling Pathway Cochlea Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Brown Fat Cell Differentiation Cellular Response To 3,3',5-triiodo-L-thyronine Positive Regulation Of Myoblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Formation of the ureteric bud
Drugs
Diseases			Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
GWAS		Adverse response to drug ( 30420678) Age-related hearing impairment ( 34108613) Appendicular lean mass ( 33097823) Asthma with severe exacerbations ( 32841424) Atrial fibrillation ( 29892015) Bone mineral density (paediatric, skull) ( 24945404) Chronic pain ( 33685280) Estimated glomerular filtration rate ( 31152163 31015462) Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Glomerular filtration rate (creatinine) ( 28452372) Heel bone mineral density ( 30598549 28869591) Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196 34021172) Hip index ( 34021172) Methadone dose in opioid dependence ( 28115739) Neutrophil count ( 32888494) Protein quantitative trait loci ( 18464913) Response to angiotensin II receptor blocker therapy ( 22566498) Triglyceride levels ( 32203549 32154731) Visceral fat ( 22589738) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 32888494)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Glaucoma ( 31959993) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 22419738 22570617 29891935) Gut microbiota (bacterial taxa) ( 27723756) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Optic disc size ( 31809533) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Refractive error ( 32231278) Vertical cup-disc ratio ( 20548946 25241763)
Interacting Genes		7 interacting genes: AATK CRYAA ERBB3 PLK1 SIX1 TRIM69 UBC	14 interacting genes: CCDC85B DACH1 EYA1 EYA2 EYA3 EYA4 MDFI PLEKHG4 POU6F2 REL TLE1 TLE3 TLE5 VTN
Entrez ID		2070	6495
HPRD ID		04648	03125
Ensembl ID		ENSG00000112319	ENSG00000126778
Uniprot IDs		A0A0S2Z3Q2 A0A0S2Z3V9 A0A8C8KDW0 B4DIV6 B4DRQ6 E9PLN6 F2Z2Y1 O95677 Q96CJ7	Q15475
PDB IDs			4EGC
Enriched GO Terms of Interacting Partners?		Cell Death Apoptotic Process Programmed Cell Death Centrosome Separation Protein Localization To Centrosome Protein Localization To Cytoskeleton Centrosome Cycle Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Mesenchyme Development Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Protein Kinase Activity Synaptonemal Complex Disassembly Microtubule Organizing Center Organization Golgi Inheritance Ureter Smooth Muscle Cell Differentiation Cellular Response To 3,3',5-triiodo-L-thyronine Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Fungiform Papilla Morphogenesis Neuron Apoptotic Process Embryonic Organ Morphogenesis Neuregulin Receptor Activity Protein Tyrosine Kinase Activity Regulation Of Branch Elongation Involved In Ureteric Bud Branching Olfactory Placode Formation Response To 3,3',5-triiodo-L-thyronine Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Facial Nerve Morphogenesis Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Animal Organ Development Kinase Activity Protein Localization To Organelle Protein Ubiquitination Myotome Development Positive Regulation Of Ureteric Bud Formation Trigeminal Ganglion Development ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Negative Regulation Of Neuron Apoptotic Process Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Protein Modification By Small Protein Conjugation Cranial Ganglion Development Sensory Organ Development Protein Localization To Nucleus Regulation Of Anaphase-promoting Complex-dependent Catabolic Process	Histone H2AXY142 Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Protein Tyrosine Phosphatase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication Negative Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Phosphoprotein Phosphatase Activity Positive Regulation Of DNA Repair Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Metabolic Process Mesodermal Cell Fate Specification Developmental Process Regulation Of DNA Metabolic Process Regulation Of DNA Repair Negative Regulation Of Apoptotic Signaling Pathway Beta-catenin-TCF Complex Positive Regulation Of DNA Metabolic Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Anoikis Regulation Of Apoptotic Signaling Pathway Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Apoptotic Process Visual Perception Sensory Perception Of Light Stimulus Sensory Perception Negative Regulation Of RNA Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Metabolic Process Transcription Corepressor Activity Anatomical Structure Morphogenesis DNA Repair Regulation Of Programmed Cell Death
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