EYA4

Description		EYA transcriptional coactivator and phosphatase 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	DNA Repair Chromatin Organization DNA Damage Response Visual Perception Anatomical Structure Morphogenesis Cell Differentiation Positive Regulation Of DNA Repair Inner Ear Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Age-related hearing impairment ( 34108613) Appendicular lean mass ( 33097823) Asthma with severe exacerbations ( 32841424) Atrial fibrillation ( 29892015) Bone mineral density (paediatric, skull) ( 24945404) Chronic pain ( 33685280) Estimated glomerular filtration rate ( 31152163 31015462) Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Glomerular filtration rate (creatinine) ( 28452372) Heel bone mineral density ( 30598549 28869591) Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196 34021172) Hip index ( 34021172) Methadone dose in opioid dependence ( 28115739) Neutrophil count ( 32888494) Protein quantitative trait loci ( 18464913) Response to angiotensin II receptor blocker therapy ( 22566498) Triglyceride levels ( 32203549 32154731) Visceral fat ( 22589738) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: AATK CRYAA ERBB3 PLK1 SIX1 TRIM69 UBC
Entrez ID		2070
HPRD ID		04648
Ensembl ID		ENSG00000112319
Uniprot IDs		A0A0S2Z3Q2 A0A0S2Z3V9 A0A8C8KDW0 B4DIV6 B4DRQ6 E9PLN6 F2Z2Y1 O95677 Q96CJ7
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Death Apoptotic Process Programmed Cell Death Centrosome Separation Protein Localization To Centrosome Protein Localization To Cytoskeleton Centrosome Cycle Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Mesenchyme Development Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Protein Kinase Activity Synaptonemal Complex Disassembly Microtubule Organizing Center Organization Golgi Inheritance Ureter Smooth Muscle Cell Differentiation Cellular Response To 3,3',5-triiodo-L-thyronine Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Fungiform Papilla Morphogenesis Neuron Apoptotic Process Embryonic Organ Morphogenesis Neuregulin Receptor Activity Protein Tyrosine Kinase Activity Regulation Of Branch Elongation Involved In Ureteric Bud Branching Olfactory Placode Formation Response To 3,3',5-triiodo-L-thyronine Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Facial Nerve Morphogenesis Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Animal Organ Development Kinase Activity Protein Localization To Organelle Protein Ubiquitination Myotome Development Positive Regulation Of Ureteric Bud Formation Trigeminal Ganglion Development ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Negative Regulation Of Neuron Apoptotic Process Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Protein Modification By Small Protein Conjugation Cranial Ganglion Development Sensory Organ Development Protein Localization To Nucleus Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
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