PTPRZ1 and IL34

Number of citations of the paper that reports this interaction (PubMedID 23744080)
80

Data Source:
BioGRID (pull down)

		PTPRZ1	IL34
Description		protein tyrosine phosphatase receptor type Z1	interleukin 34
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Extracellular Matrix Synapse Perineuronal Net	Extracellular Region Extracellular Space
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding Hydrolase Activity	Cytokine Activity Macrophage Colony-stimulating Factor Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Protein Dephosphorylation Signal Transduction Axonogenesis Central Nervous System Development Learning Or Memory Neuron Projection Development Regulation Of Myelination Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation	Positive Regulation Of Protein Phosphorylation Immune System Process Inflammatory Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cell Development Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Multicellular Organismal Process Interleukin-34-mediated Signaling Pathway Microglial Cell Proliferation Positive Regulation Of Macrophage Proliferation Regulation Of Multicellular Organismal Development
Pathways		Other interleukin signaling MDK and PTN in ALK signaling	Other interleukin signaling Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Diseases
GWAS		Hand grip strength ( 27325353) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730)	Alzheimer's disease ( 34099642) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Cerebrospinal P-tau181p levels ( 28247064) Diffuse cutaneous systemic sclerosis ( 29293537) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Intraocular pressure ( 29785010 30054594) Malaria ( 31844061)
Interacting Genes		13 interacting genes: ADD2 ALK ARHGAP35 CTNNB1 FYN GIT1 HMGB1 IL34 MDK MGAT5B PTN PTPRF TNR	3 interacting genes: ATXN1 LCE1F PTPRZ1
Entrez ID		5803	146433
HPRD ID		01481	14582
Ensembl ID		ENSG00000106278	ENSG00000157368
Uniprot IDs		B4DFE7 P23471	J3QQT3 Q6ZMJ4
PDB IDs		3JXF 3S97 5AWX 5H08 8FN8 8FN9	4DKC 4DKD 4DKE 4DKF
Enriched GO Terms of Interacting Partners?		Regulation Of Response To Wounding Cell Migration Regulation Of Oligodendrocyte Differentiation Regulation Of Neuron Projection Development Cell Motility Positive Regulation Of Neuron Projection Development Regulation Of Glial Cell Differentiation Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Developmental Process Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Component Organization Regulation Of Cell Projection Organization Leukocyte Migration Regulation Of Gliogenesis Schaffer Collateral - CA1 Synapse Positive Regulation Of Leukocyte Chemotaxis Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Development Learning Or Memory Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Glial Cell Differentiation Cell Development Nervous System Development Cognition Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Growth Factor Activity Heparin Binding Positive Regulation Of Blood Vessel Branching Learning Positive Regulation Of Cell Projection Organization Regulation Of Multicellular Organismal Development Regulation Of Neurogenesis Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway System Development Regulation Of Blood Vessel Branching Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Gliogenesis Positive Regulation Of Epithelial Cell Proliferation Response To Mechanical Stimulus Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Development	Positive Regulation Of Gliogenesis Regulation Of Gliogenesis Learning Or Memory Positive Regulation Of Neurogenesis Positive Regulation Of Nervous System Development POZ Domain Binding Regulation Of Oligodendrocyte Progenitor Proliferation Cognition Positive Regulation Of Cell Development Regulation Of Neurogenesis Regulation Of Nervous System Development Perineuronal Net Poly(G) Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Nuclear Inclusion Body Transmembrane Receptor Protein Tyrosine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Oligodendrocyte Differentiation Poly(U) RNA Binding Positive Regulation Of Glial Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Oligodendrocyte Differentiation Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Regulation Of Cell Development Regulation Of Myelination Nervous System Process Positive Regulation Of Cell Differentiation Regulation Of Glial Cell Proliferation Insulin-like Growth Factor Receptor Signaling Pathway Lung Alveolus Development
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