ISL2 and LHX3

Number of citations of the paper that reports this interaction (PMID 9452425)
36

Data Source:
HPRD (in vitro, in vivo)

		ISL2	LHX3
Gene Name		ISL LIM homeobox 2	LIM homeobox 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Transcription Factor Complex
	Molecular Function	DNA Binding Zinc Ion Binding Sequence-specific DNA Binding	RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Spinal Cord Motor Neuron Cell Fate Specification Visceral Motor Neuron Differentiation Retinal Ganglion Cell Axon Guidance Negative Regulation Of Neuron Differentiation Neuron Development Peripheral Nervous System Neuron Development	Placenta Development Transcription From RNA Polymerase II Promoter Motor Neuron Axon Guidance Organ Morphogenesis Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Inner Ear Development
Pathways
Drugs
Diseases
GWAS			Height ( 20189936) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		2 interactors: ISL1 LHX3	8 interactors: CITED2 IFT172 ISL1 ISL2 LDB1 LHX1 LMX1A RLIM
Entrez ID		64843	8022
HPRD ID		11053	02783
Ensembl ID		ENSG00000159556	ENSG00000107187
Uniprot IDs		Q96A47	F1T0D5 F1T0D7 F1T0D9 Q9UBR4
PDB IDs
Enriched GO Terms of Interacting Partners?		Spinal Cord Motor Neuron Cell Fate Specification Neuron Fate Specification Spinal Cord Motor Neuron Differentiation Pituitary Gland Development Ventral Spinal Cord Development Cell Differentiation In Spinal Cord Neuron Fate Commitment Diencephalon Development Cell Fate Specification Spinal Cord Development Central Nervous System Neuron Differentiation Cell Fate Commitment Positive Regulation Of Granulocyte Colony-stimulating Factor Production Positive Regulation Of Macrophage Colony-stimulating Factor Production Medial Motor Column Neuron Differentiation Regulation Of Macrophage Colony-stimulating Factor Production Peripheral Nervous System Neuron Axonogenesis Visceral Motor Neuron Differentiation Axon Guidance Sensory System Development Negative Regulation Of Protein Homodimerization Activity Cardiac Cell Fate Determination Forebrain Development Pattern Specification Process Gland Development Positive Regulation Of Interleukin-1 Alpha Production Axonogenesis Axon Development Somatic Motor Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Neuron Projection Morphogenesis Trigeminal Nerve Development Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Peripheral Nervous System Neuron Development Regulation Of Secondary Heart Field Cardioblast Proliferation Brain Development Cardiac Muscle Cell Myoblast Differentiation Ventral Spinal Cord Interneuron Specification Head Development Neuron Projection Development Spinal Cord Association Neuron Differentiation Cell Projection Morphogenesis Outflow Tract Septum Morphogenesis Cardioblast Differentiation Cell Part Morphogenesis Secondary Heart Field Specification Transcription From RNA Polymerase II Promoter	Central Nervous System Neuron Differentiation Ventral Spinal Cord Development Cell Differentiation In Spinal Cord Spinal Cord Development Axis Specification Central Nervous System Development Pattern Specification Process Visceral Motor Neuron Differentiation Neuron Differentiation Spinal Cord Motor Neuron Differentiation Anatomical Structure Morphogenesis Brain Development Generation Of Neurons Head Development Cell Projection Morphogenesis Neurogenesis Cell Part Morphogenesis Organ Development Axon Guidance Peripheral Nervous System Neuron Development Cerebellum Development Left/right Axis Specification Metencephalon Development Anatomical Structure Formation Involved In Morphogenesis Cell Morphogenesis Cell Differentiation Cerebellar Purkinje Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Spinal Cord Motor Neuron Cell Fate Specification Embryo Development Cell Projection Organization Cerebellar Purkinje Cell Layer Morphogenesis Axonogenesis Nervous System Development Transcription, DNA-templated Hindbrain Development Axon Development Left/right Pattern Formation Retinal Ganglion Cell Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Organ Morphogenesis RNA Biosynthetic Process Negative Regulation Of Gene Expression Chemotaxis Negative Regulation Of Biosynthetic Process Negative Regulation Of Neuron Differentiation Neuron Projection Morphogenesis Cerebellar Cortex Formation
Tagcloud ?		ablated abundant belong belongs brdu crypt endoderm endodermal gut homeobox intestine isl1 islet1 ldb ldb1 ldb2 lhx lhx1 lim lineages lmx1a lmx1b mesodermal obligatory patterning prominently quiescent terminally tracing	balanced binary circuit collaboration cord directing diversification enhancers excitatory expense fate gabaergic gata2 generating glutamatergic immature initiates interneuons interneuron interneurons lim lmo4 nli nucleates spinal v2 v2a v2b ventral
Tagcloud (Difference) ?		ablated abundant belong belongs brdu crypt endoderm endodermal gut homeobox intestine isl1 islet1 ldb ldb1 ldb2 lhx lhx1 lineages lmx1a lmx1b mesodermal obligatory patterning prominently quiescent terminally tracing	balanced binary circuit collaboration cord directing diversification enhancers excitatory expense fate gabaergic gata2 generating glutamatergic immature initiates interneuons interneuron interneurons lmo4 nli nucleates spinal v2 v2a v2b ventral
Tagcloud (Intersection) ?		lim