ISL2 and ISL1

Number of citations of the paper that reports this interaction (PMID 9452425)
36

Data Source:
HPRD (in vivo)

		ISL2	ISL1
Gene Name		ISL LIM homeobox 2	ISL LIM homeobox 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Mitochondrion
	Molecular Function	DNA Binding Zinc Ion Binding Sequence-specific DNA Binding	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity Enhancer Sequence-specific DNA Binding Chromatin Binding Zinc Ion Binding Ligand-dependent Nuclear Receptor Binding Estrogen Receptor Binding BHLH Transcription Factor Binding
	Biological Process	Regulation Of Transcription, DNA-templated Spinal Cord Motor Neuron Cell Fate Specification Visceral Motor Neuron Differentiation Retinal Ganglion Cell Axon Guidance Negative Regulation Of Neuron Differentiation Neuron Development Peripheral Nervous System Neuron Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neural Crest Cell Migration Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Vascular Endothelial Growth Factor Production Spinal Cord Motor Neuron Cell Fate Specification Spinal Cord Motor Neuron Differentiation Visceral Motor Neuron Differentiation Trigeminal Nerve Development Pituitary Gland Development Pancreas Development Axon Regeneration Retinal Ganglion Cell Axon Guidance Positive Regulation Of Insulin Secretion Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Fate Specification Mesenchymal Cell Differentiation Sensory System Development Peripheral Nervous System Neuron Axonogenesis Negative Regulation Of Inflammatory Response Ventricular Cardiac Muscle Tissue Morphogenesis Pharyngeal System Development Cardiac Muscle Cell Myoblast Differentiation Innervation Atrial Septum Morphogenesis Cardiac Cell Fate Determination Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Protein Homodimerization Activity Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Macrophage Colony-stimulating Factor Production
Pathways			Peptide hormone metabolism Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS			Dental caries ( 23259602)
Protein-Protein Interactions		2 interactors: ISL1 LHX3	20 interactors: APP CDK6 CDKN2B ESR1 ISL2 KDM1A LDB1 LDB2 LHX1 LHX3 LHX4 LMO2 LMX1A NR2F1 PECR RELA RLIM SMAD3 SSBP4 ZNF511
Entrez ID		64843	3670
HPRD ID		11053	02650
Ensembl ID		ENSG00000159556	ENSG00000016082
Uniprot IDs		Q96A47	P61371
PDB IDs
Enriched GO Terms of Interacting Partners?		Spinal Cord Motor Neuron Cell Fate Specification Neuron Fate Specification Spinal Cord Motor Neuron Differentiation Pituitary Gland Development Ventral Spinal Cord Development Cell Differentiation In Spinal Cord Neuron Fate Commitment Diencephalon Development Cell Fate Specification Spinal Cord Development Central Nervous System Neuron Differentiation Cell Fate Commitment Positive Regulation Of Granulocyte Colony-stimulating Factor Production Positive Regulation Of Macrophage Colony-stimulating Factor Production Medial Motor Column Neuron Differentiation Regulation Of Macrophage Colony-stimulating Factor Production Peripheral Nervous System Neuron Axonogenesis Visceral Motor Neuron Differentiation Axon Guidance Sensory System Development Negative Regulation Of Protein Homodimerization Activity Cardiac Cell Fate Determination Forebrain Development Pattern Specification Process Gland Development Positive Regulation Of Interleukin-1 Alpha Production Axonogenesis Axon Development Somatic Motor Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Neuron Projection Morphogenesis Trigeminal Nerve Development Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Peripheral Nervous System Neuron Development Regulation Of Secondary Heart Field Cardioblast Proliferation Brain Development Cardiac Muscle Cell Myoblast Differentiation Ventral Spinal Cord Interneuron Specification Head Development Neuron Projection Development Spinal Cord Association Neuron Differentiation Cell Projection Morphogenesis Outflow Tract Septum Morphogenesis Cardioblast Differentiation Cell Part Morphogenesis Secondary Heart Field Specification Transcription From RNA Polymerase II Promoter	Organ Development Positive Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process System Development Cell Differentiation Gene Expression Central Nervous System Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Differentiation Multicellular Organismal Development Anatomical Structure Development Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Central Nervous System Neuron Differentiation Regulation Of Erythrocyte Differentiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Developmental Process Forebrain Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Brain Development Biosynthetic Process Generation Of Neurons Head Development Cellular Nitrogen Compound Metabolic Process Ventral Spinal Cord Development Positive Regulation Of Metabolic Process Neurogenesis Cell Differentiation In Spinal Cord Nervous System Development Response To External Stimulus Axon Guidance Nitrogen Compound Metabolic Process
Tagcloud ?		ablated abundant belong belongs brdu crypt endoderm endodermal gut homeobox intestine isl1 islet1 ldb ldb1 ldb2 lhx lhx1 lim lineages lmx1a lmx1b mesodermal obligatory patterning prominently quiescent terminally tracing	3f8 achieving antimouse b4galnt1 binary bm concordance enrollment gd2 immunoglobulin immunotherapy individualize individually kaplan killer meier missing mrd multivariable neuroblastoma os pfs phox2b postmrd postmrdsum predictive remission sum univariable
Tagcloud (Difference) ?		ablated abundant belong belongs brdu crypt endoderm endodermal gut homeobox intestine islet1 ldb ldb1 ldb2 lhx lhx1 lim lineages lmx1a lmx1b mesodermal obligatory patterning prominently quiescent terminally tracing	3f8 achieving antimouse b4galnt1 binary bm concordance enrollment gd2 immunoglobulin immunotherapy individualize individually kaplan killer meier missing mrd multivariable neuroblastoma os pfs phox2b postmrd postmrdsum predictive remission sum univariable
Tagcloud (Intersection) ?		isl1