ISL2

Description		ISL LIM homeobox 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Axonogenesis Spinal Cord Motor Neuron Cell Fate Specification Visceral Motor Neuron Differentiation Neuron Differentiation Retinal Ganglion Cell Axon Guidance Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Neuron Fate Specification Neuron Development Peripheral Nervous System Neuron Development
Pathways
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31015462)
Interacting Genes		2 interacting genes: ISL1 LHX3
Entrez ID		64843
HPRD ID		11053
Ensembl ID		ENSG00000159556
Uniprot IDs		Q96A47
PDB IDs
Enriched GO Terms of Interacting Partners?		Spinal Cord Motor Neuron Cell Fate Specification Neuron Fate Specification Pituitary Gland Development Cell Differentiation In Spinal Cord Cell Fate Specification Central Nervous System Neuron Differentiation Transcription Regulator Complex Neuron Projection Guidance Regionalization Gland Development Transcription Cis-regulatory Region Binding Axon Guidance RNA Polymerase II-specific DNA-binding Transcription Factor Binding Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Visceral Motor Neuron Differentiation Positive Regulation Of Macrophage Colony-stimulating Factor Production Peripheral Nervous System Neuron Axonogenesis Positive Regulation Of Granulocyte Colony-stimulating Factor Production Neuron Differentiation Cardiac Cell Fate Determination Ventral Spinal Cord Interneuron Specification Somatotropin Secreting Cell Differentiation Sinoatrial Node Cell Development Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Pattern Specification Process Sensory System Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Trigeminal Nerve Development Regulation Of Macrophage Colony-stimulating Factor Production Thyroid-stimulating Hormone-secreting Cell Differentiation Sequence-specific DNA Binding LIM Domain Binding Regulation Of Secondary Heart Field Cardioblast Proliferation Neuron Projection Development Positive Regulation Of Interleukin-1 Alpha Production Animal Organ Morphogenesis Negative Regulation Of Mesenchymal Cell Proliferation Peripheral Nervous System Neuron Development Cardiac Muscle Cell Myoblast Differentiation Regulation Of Cardioblast Proliferation Secondary Heart Field Specification Spinal Cord Association Neuron Differentiation Heart Field Specification Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Cardiac Right Ventricle Morphogenesis Cardioblast Differentiation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Atrial Septum Morphogenesis
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