GMNC and CCNE1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GMNC	CCNE1
Description		geminin coiled-coil domain containing	cyclin E1
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GO Annotations	Cellular Component	Extracellular Region Nucleus	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Cyclin E1-CDK2 Complex
	Molecular Function	Chromatin Binding Protein Binding	Protein Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	DNA Replication Spermatogenesis Single Fertilization Regulation Of DNA-templated DNA Replication Initiation Multicellular Organism Growth Negative Regulation Of Cell Cycle Cilium Assembly Seminiferous Tubule Development Cerebrospinal Fluid Circulation Multi-ciliated Epithelial Cell Differentiation	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Replication Initiation Protein Phosphorylation Homologous Chromosome Pairing At Meiosis Wnt Signaling Pathway Regulation Of Protein Localization Cell Division Regulation Of Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mesenchymal Stem Cell Proliferation
Pathways			G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response PTK6 Regulates Cell Cycle Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) RHOBTB3 ATPase cycle
Drugs
Diseases			Laryngeal cancer Gastric cancer
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Cortical surface area (MOSTest) ( 32665545) Lateral thalamic nuclei volume ( 34006833) Medial thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545) Ventral thalamic nuclei volume ( 34006833)	Adult body size ( 32376654) Bladder cancer ( 20972438 24163127) Body mass index ( 25673413) Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Diastolic blood pressure ( 27841878 28135244) Medication use (diuretics) ( 31015401) Response to fenofibrate (total cholesterol levels) ( 27002377) Spatial processing ( 31596458) Walking pace ( 33128006)
Interacting Genes		1 interacting genes: CCNE1	71 interacting genes: AKT1 AR ARHGEF5 ARID4A ARIH1 ARNT AURKA BRCA2 BTRC CABLES1 CALM1 CCND2 CCT4 CDC25A CDC6 CDK1 CDK2 CDK3 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C COIL CUL3 FBXW7 FGFR4 FOXM1 FZR1 GLIS2 GMNC GRM1 GSK3B H1-0 H1-1 H1-5 HERC5 KAT2A KPNB1 LATS2 LINC00664 MARCKS MCM3 MRE11 MYBL2 MYC NBN NF2 PIN1 POLD1 PRC1 PRKAR1A PTPA RASSF1 RB1 RBL1 RBL2 REL RHOBTB3 RRN3 SKP2 SMARCA4 SMARCC1 SMARCD3 SPOP STK11 TERT TP73 TSC1 UBTF
Entrez ID		647309	898
HPRD ID			00455
Ensembl ID		ENSG00000205835	ENSG00000105173
Uniprot IDs		A6NCL1	A0A0G3DHS8 P24864 V5W5X2
PDB IDs		5C9N	1W98 5L2W 7KJS 7XQK 8H4R 8H6P 8H6T 8VQ3 8VQ4
Enriched GO Terms of Interacting Partners?		Cyclin E1-CDK2 Complex Positive Regulation Of Mesenchymal Stem Cell Proliferation DNA Replication Initiation Homologous Chromosome Pairing At Meiosis Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Positive Regulation Of Stem Cell Proliferation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Chromosome Organization Involved In Meiotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Microtubule Organizing Center Telomere Maintenance Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Stem Cell Proliferation Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Telomere Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition	Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Nucleus Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of DNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Population Proliferation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA Metabolic Process Cyclin Binding Negative Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Cell Population Proliferation Cellular Response To Stress Cell Division Regulation Of Protein Localization To Nucleus Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Modification Process Regulation Of Signal Transduction Regulation Of Chromosome Organization Cyclin-dependent Protein Kinase Holoenzyme Complex Negative Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Macromolecule Metabolic Process G2/M Transition Of Mitotic Cell Cycle
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