PDIA2 and SST

Number of citations of the paper that reports this interaction (PMID 15590633)
6

Data Source:
BioGRID (pull down)

		PDIA2	SST
Gene Name		protein disulfide isomerase family A, member 2	somatostatin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Extracellular Region Extracellular Space Neuronal Cell Body
	Molecular Function	Protein Disulfide Isomerase Activity Steroid Binding Protein Binding Peptidyl-proline 4-dioxygenase Activity	Hormone Activity
	Biological Process	Protein Folding Protein Retention In ER Lumen Peptidyl-proline Hydroxylation Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Hyperosmotic Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Synaptic Transmission Response To Nutrient Digestion Negative Regulation Of Cell Proliferation Hormone-mediated Apoptotic Signaling Pathway Response To Heat Regulation Of Cell Migration Response To Drug Response To Amino Acid Response To Steroid Hormone
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Cysteamine
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CALR COL2A1 CUL3 GAPDH P4HTM PPARG SST	6 interactors: PDIA2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5
Entrez ID		64714	6750
HPRD ID		07617	08920
Ensembl ID		ENSG00000185615	ENSG00000157005
Uniprot IDs		Q13087	P61278
PDB IDs			1P2W
Enriched GO Terms of Interacting Partners?		Cellular Response To Lithium Ion Response To Lithium Ion Cellular Response To Organic Substance Positive Regulation Of Phagocytosis Apoptotic Process Programmed Cell Death Cell Death Death Negative Regulation Of Signal Transduction Regulation Of Phagocytosis Negative Regulation Of Signaling Response To Organic Substance Response To Steroid Hormone Negative Regulation Of Translation Response To Metformin Low-density Lipoprotein Particle Receptor Biosynthetic Process Peptide Antigen Assembly With MHC Class I Protein Complex Negative Regulation Of Pancreatic Stellate Cell Proliferation Peptidyl-cysteine S-trans-nitrosylation Response To Diuretic Protein Stabilization Response To Drug Heart Development Positive Regulation Of Endocytosis Regulation Of Cell Proliferation Regulation Of DNA Replication Cellular Response To Metal Ion Regulation Of Cholesterol Transporter Activity Cellular Response To Vitamin E Hormone-mediated Signaling Pathway Regulation Of Protein Stability Cellular Response To Inorganic Substance Cell Cycle Arrest Trophectodermal Cellular Morphogenesis Sequestering Of Calcium Ion Regulation Of Endocytosis Negative Regulation Of Cellular Protein Metabolic Process Response To Temperature Stimulus Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Peptidyl-cysteine S-nitrosylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Response To Lipid Cardiovascular System Development Response To Estrogen Response To Organic Cyclic Compound Negative Regulation Of Protein Metabolic Process Negative Regulation Of Receptor Biosynthetic Process Peroxisome Proliferator Activated Receptor Signaling Pathway	Somatostatin Signaling Pathway Cellular Response To Estradiol Stimulus Neuropeptide Signaling Pathway Cellular Response To Estrogen Stimulus Hormone-mediated Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Organic Cyclic Compound Response To Estradiol Cellular Response To Lipid Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Steroid Hormone Response To Peptide Response To Glucocorticoid Response To Corticosteroid Cellular Response To Hormone Stimulus Synaptic Transmission Response To Estrogen Negative Regulation Of Cell Proliferation Response To Organonitrogen Compound Response To Lipid Response To Organic Cyclic Compound Cell-cell Signaling Response To Hormone G-protein Coupled Receptor Signaling Pathway Forebrain Development Cerebellum Development Metencephalon Development Regulation Of Cell Proliferation Hindbrain Development Response To Starvation Brain Development Cellular Response To Organic Substance Head Development Central Nervous System Development Response To Organic Substance Response To Nutrient Levels Response To Extracellular Stimulus Spermatogenesis Male Gamete Generation Cell Surface Receptor Signaling Pathway Digestion Gamete Generation Cellular Response To Stimulus Sexual Reproduction
Tagcloud ?		calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia3 pdia4 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization	additional allow alphac barley cdna cerevisiae encoding entry fructan fructosyltransferase fusion hordeum incubated methylotrophic pastoris pichia ppicz produced pronounced saccharomyces secreted secretory sft sucrose transformed translational vector vulgare yeast
Tagcloud (Difference) ?		calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia3 pdia4 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization	additional allow alphac barley cdna cerevisiae encoding entry fructan fructosyltransferase fusion hordeum incubated methylotrophic pastoris pichia ppicz produced pronounced saccharomyces secreted secretory sft sucrose transformed translational vector vulgare yeast
Tagcloud (Intersection) ?