PDIA2 and KRTAP12-1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PDIA2	KRTAP12-1
Description		protein disulfide isomerase family A member 2	keratin associated protein 12-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Protein Disulfide Isomerase Activity Steroid Binding Protein Binding Lipid Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Isomerase Activity	Protein Binding
	Biological Process	Protein Folding Protein Retention In ER Lumen Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Platelet Aggregation
Pathways		Developmental Lineage of Pancreatic Acinar Cells	Keratinization
Drugs
Diseases
GWAS		Body mass index ( 26426971) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		12 interacting genes: ACTB CALR COL2A1 CUL3 GAPDH KRTAP12-1 KRTAP6-1 MAPT P4HTM PPARG SNCA SST	62 interacting genes: CATSPER1 CHRD CYSRT1 DHRS1 ENKD1 FHL3 GATA3 GPRIN2 GRN HOXA1 HOXC8 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP15-1 KRTAP26-1 KRTAP3-2 KRTAP4-4 KRTAP4-5 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1E LCE1F LCE2A LCE2B LCE2C LCE3A LCE5A MEOX2 MGAT5B NBPF19 NEU4 NOTCH2NLA OTX1 PDIA2 PDIA4 PEF1 POU2AF1 POU4F2 PRR35 RBPMS SMCP TOX TRIP13 UBQLN2 VGLL3 ZIC1
Entrez ID		64714	353332
HPRD ID		07617	11197
Ensembl ID		ENSG00000185615	ENSG00000187175
Uniprot IDs		Q13087	P59990
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Norepinephrine Uptake Transporter Regulator Activity Identical Protein Binding Negative Regulation Of Mitochondrial Fission Regulation Of Organelle Organization Regulation Of Multicellular Organismal Process Regulation Of Synaptic Vesicle Recycling Peptide Binding Regulation Of Protein Stability Hormone-mediated Signaling Pathway Regulation Of Mitochondrial Fission Microglial Cell Activation Amyloid Fibril Formation Leukocyte Activation Involved In Inflammatory Response Cytosol Cytoskeleton Organization Cellular Response To Oxidative Stress Kinesin Binding Tau Protein Binding Regulation Of Chromosome Organization Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Postsynapse Negative Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process Microtubule Binding Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Biological Quality Cellular Response To Chemical Stress Protein Destabilization Cellular Response To Growth Factor Stimulus Macrophage Activation Regulation Of Microtubule Polymerization Positive Regulation Of Reactive Oxygen Species Metabolic Process Response To Xenobiotic Stimulus Homeostatic Process Regulation Of Endocytosis Response To Metal Ion Response To Growth Factor Apoptotic Signaling Pathway Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Neurofibrillary Tangle Assembly	Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Identical Protein Binding Protein Binding
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