COPS7B and EIF3E

Number of citations: 0 (PubMedID 12220626)
Data Source: HPRD (in vivo)

		COPS7B	EIF3E
Name		COP9 signalosome subunit 7B	eukaryotic translation initiation factor 3 subunit E
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Protein-containing Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Postsynaptic Density Membrane Eukaryotic 43S Preinitiation Complex PML Body Protein-containing Complex Eukaryotic 48S Preinitiation Complex Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3e
	Molecular Function	Protein Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Cadherin Binding
	Biological Process	Protein Deneddylation COP9 Signalosome Assembly Regulation Of Protein Neddylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Regulation Of Translational Initiation Positive Regulation Of Translation Negative Regulation Of Translational Initiation
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
GWAS		Height ( 18391951 )	Brain morphology (MOSTest) ( 32665545 ) Coffee consumption ( 31046077 ) Dupuytren's disease ( 21732829 28886342 ) Heel bone mineral density ( 30598549 ) Macular thickness ( 30535121 ) Male-pattern baldness ( 28196072 ) Ossification of the posterior longitudinal ligament of the spine ( 25064007 )
Interacting Genes		6 interacting genes: APP BEX5 EIF3E NMI PMF1 UBC	37 interacting genes: ANKHD1 ATM COPS6 COPS7A COPS7B COPS8 DDX24 EIF3C EIF3L EIF4ENIF1 EPAS1 EPN2 GPAA1 GPBP1L1 HAP1 IFIT1 ISCA2 KPRP LINC01554 MAPK1IP1L MIIP MRNIP MSI2 NDRG1 NSF OGT PGCKA1 PRPF31 PRRC2A RPSA RUNDC3A SHBG SMAD9 TRIM27 TRIM55 TRIM63 ZNF48
Entrez ID		64708	3646
HPRD ID		09889	03734
Ensembl ID		ENSG00000144524	ENSG00000104408
Uniprot IDs		A0A087X1P5 J3KQ34 J3KQ41 Q6ZTQ7 Q9H9Q2	P60228
PDB IDs		6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F	3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN
GO Terms Enriched among Interactors		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Positive Regulation Of Inflammatory Response Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Macrophage Activation Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Myeloid Leukocyte Activation Growth Factor Receptor Binding Main Axon Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Negative Regulation Of Interferon-alpha Production Positive Regulation Of Protein K48-linked Ubiquitination MIS12/MIND Type Complex Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Protein Metabolic Process NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Protein K48-linked Ubiquitination Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion	Regulation Of Protein Neddylation Protein Deneddylation COP9 Signalosome Assembly COP9 Signalosome Regulation Of Post-translational Protein Modification Protein Neddylation Regulation Of Protein Metabolic Process Protein Modification By Small Protein Removal RNA Binding Negative Regulation Of Cell Cycle G2/M Phase Transition Post-translational Protein Modification Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoplasm Regulation Of Protein Modification Process Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Protein K63-linked Ubiquitination Eukaryotic 43S Preinitiation Complex Protein Modification By Small Protein Conjugation Protein Metabolic Process