COPS7B and PMF1

Number of citations: 23 (PubMedID 12020345)
Data Source: HPRD (two hybrid)

		COPS7B	PMF1
Name		COP9 signalosome subunit 7B	polyamine modulated factor 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Protein-containing Complex	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Golgi Apparatus Cytosol
	Molecular Function	Protein Binding	Transcription Coactivator Activity Protein Binding Leucine Zipper Domain Binding
	Biological Process	Protein Deneddylation COP9 Signalosome Assembly Regulation Of Protein Neddylation	Transcription By RNA Polymerase II Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of DNA-templated Transcription Cell Division
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
GWAS		Height ( 18391951 )	Estimated glomerular filtration rate ( 30604766 ) Intracerebral hemorrhage ( 24656865 ) Longevity (age >99th survival percentile) ( 31413261 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269 ) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377 ) Paclitaxel disposition in epithelial ovarian cancer ( 29367611 ) White matter hyperintensity burden ( 25663218 )
Interacting Genes		6 interacting genes: APP BEX5 EIF3E NMI PMF1 UBC	23 interacting genes: BICD2 CEP126 COPS6 COPS7A COPS7B CRMP1 DSN1 EFHC1 FBXO28 GDF9 GIT1 HSP90AA1 KDM1A MED31 MESD MIS12 NFE2L2 PTN SHC3 SUGT1 TBC1D21 TCP10L USHBP1
Entrez ID		64708	11243
HPRD ID		09889	11441
Ensembl ID		ENSG00000144524	ENSG00000160783
Uniprot IDs		A0A087X1P5 J3KQ34 J3KQ41 Q6ZTQ7 Q9H9Q2	Q6P1K2
PDB IDs		6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F	5LSJ 5LSK 8PPR 8Q5H
GO Terms Enriched among Interactors		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Positive Regulation Of Inflammatory Response Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Macrophage Activation Axon Midline Choice Point Recognition Cell Activation Involved In Immune Response Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Myeloid Leukocyte Activation Growth Factor Receptor Binding Main Axon Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Eukaryotic Translation Initiation Factor 3 Complex, EIF3e Negative Regulation Of Interferon-alpha Production Positive Regulation Of Protein K48-linked Ubiquitination MIS12/MIND Type Complex Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Protein Metabolic Process NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Regulation Of Protein K48-linked Ubiquitination Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion	Protein Deneddylation Regulation Of Protein Neddylation Regulation Of Post-translational Protein Modification Skeletal Muscle Satellite Cell Proliferation COP9 Signalosome COP9 Signalosome Assembly MIS12/MIND Type Complex Spindle Pole Kinetochore Skeletal Muscle Cell Proliferation Positive Regulation Of Cell Size Kinetochore Assembly Centrosome Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Kinetochore Organization Microtubule Cytoskeleton Organization Outer Kinetochore Protein Neddylation Protein-containing Complex Protein Modification By Small Protein Removal Post-translational Protein Modification Ossification CTP Binding DATP Binding Regulation Of Protein Modification Process Response To Antibiotic Protein Tyrosine Kinase Binding Positive Regulation Of Cell Projection Organization Positive Regulation Of Neuron Projection Development Positive Regulation Of Glutathione Biosynthetic Process Mediator Complex Spindle Organization Chromosome, Centromeric Region Negative Regulation Of ARF Protein Signal Transduction Attachment Of Spindle Microtubules To Kinetochore Cell Redox Homeostasis Regulation Of Response To Wounding Regulation Of Neuroblast Proliferation Regulation Of Cell Division Muscle Cell Proliferation Protein Modification By Small Protein Conjugation