FAM3A and MAL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		FAM3A	MAL2
Description		FAM3 metabolism regulating signaling molecule A	mal, T cell differentiation protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Plasma Membrane Endomembrane System Membrane Apical Plasma Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Carbohydrate Binding	Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Glucose Metabolic Process ATP Biosynthetic Process Mitochondrion Organization Response To Glucose Gene Expression Antifungal Humoral Response Insulin Secretion Calcium Ion Homeostasis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Antifungal Innate Immune Response	Myelination
Pathways
Drugs
Diseases
GWAS		Eosinophil count ( 32888494) Hemoglobin levels ( 26366553) Red blood cell traits ( 23446634)	Aspartate aminotransferase levels ( 33547301) Blood pressure (smoking interaction) ( 25189868) Gallstone disease ( 30504769) Hippocampal atrophy ( 19668339) Osteoprotegerin levels ( 25080503)
Interacting Genes		9 interacting genes: ANP32B APP CLEC7A CREB3 MAL2 MEOX2 MS4A12 PACRGL UBC	49 interacting genes: ABCG8 AQP6 ARFIP2 ARL13B ATP6V0E1 CD160 CD68 COQ8A CREB3 CREB3L1 ECPAS FAM3A GAD1 GAD2 GJB1 GPR152 HSFX1 HSFX2 MRM1 MTERF3 MUC1 NDRG4 NFAM1 PBX3 PIMREG PITPNC1 POLL PPP1CA PTPN9 RAB37 REEP4 RETREG3 S100B SCN3B SGK1 SH3GL1 SH3GLB1 SHMT2 SLC35H1 SUCLA2 TBRG4 THAP4 TMEM14B TPD52 TPD52L1 TPD52L2 TTPA TUBB VARS2
Entrez ID		60343	114569
HPRD ID		06505	14351
Ensembl ID		ENSG00000071889	ENSG00000147676
Uniprot IDs		D3DWX8 P98173 Q5HY75 Q9BU27	Q969L2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Superoxide Anion Generation Response To Yeast Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Metabolic Process Regulation Of Monocyte Chemotaxis Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Amylin Binding Positive Regulation Of Toll Signaling Pathway Defense Response To Fungus Response To Fungus Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Deacetylase Activity Detection Of Yeast Detection Of Molecule Of Fungal Origin Positive Regulation Of Transport Positive Regulation Of Interleukin-1 Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Roof Of Mouth Development Acetylcholine Receptor Activator Activity Positive Regulation Of Mononuclear Cell Migration Regulation Of Cell Migration Positive Regulation Of Interleukin-6 Production Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Leukocyte Chemotaxis Regulation Of Calcium-mediated Signaling Lipoprotein Particle Positive Regulation Of Protein Import Detection Of Fungus (1->3)-beta-D-glucan Binding PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Chemokine Production Regulation Of Interleukin-1 Production Regulation Of Locomotion Positive Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium	Succinate Metabolic Process Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Gamma-aminobutyric Acid Biosynthetic Process
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