PGA4 and AMIGO1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PGA4	AMIGO1
Description		pepsinogen A4	adhesion molecule with Ig like domain 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Exosome Multivesicular Body Lumen	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Dendrite Neuronal Cell Body Membrane Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Pericellular Basket
	Molecular Function	Aspartic-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity	Protein Binding Potassium Channel Regulator Activity
	Biological Process	Proteolysis Digestion	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Nervous System Development Axonogenesis Axonal Fasciculation Brain Development Positive Regulation Of Neuron Projection Development Cell Differentiation Myelination Positive Regulation Of Axonogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Nervous System Development Positive Regulation Of Synapse Assembly Neuron Projection Fasciculation Positive Regulation Of Potassium Ion Transmembrane Transport Cellular Response To L-glutamate
Pathways		Surfactant metabolism
Drugs
Diseases
GWAS			Chronic kidney disease ( 20383146) Intelligence (MTAG) ( 29326435) LDL cholesterol levels ( 32203549) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189)
Interacting Genes		9 interacting genes: AMIGO1 C16orf92 CD74 FNDC9 HHLA2 PVR SPAG4 STOM TMEM106C	35 interacting genes: ADIPOQ AMIGO2 AMIGO3 ANKRD46 ASGR1 BNIP3 C3orf52 CLDN11 CXCL9 EDDM3B GJB2 HHATL IGFBP5 LMO3 MALL NINJ2 NKG7 PGA4 PGAP2 PLPP6 PROM2 PTTG1IP RPRM SELENOK SLC38A1 SLC38A7 SLC41A1 STX8 TM4SF5 TMEM50B TMEM60 TMEM79 TNMD TSPO UPK2
Entrez ID		643847	57463
HPRD ID		18942	11129
Ensembl ID		ENSG00000229183	ENSG00000181754
Uniprot IDs		A0A1S5UZ02 B7Z719 P0DJD7	Q86WK6
PDB IDs		1FLH 1PSN 1PSO 1QRP 3UTL
Enriched GO Terms of Interacting Partners?			Membrane Cholesterol Binding Glutamine Transport L-glutamine Transmembrane Transporter Activity
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