TRA2B and SRSF6

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		TRA2B	SRSF6
Gene Name		transformer 2 beta homolog (Drosophila)	serine/arginine-rich splicing factor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleoplasm Nuclear Speck
	Molecular Function	Nucleotide Binding MRNA Binding Protein Binding Poly(A) RNA Binding	Nucleotide Binding RNA Binding Pre-mRNA Binding Poly(A) RNA Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Splice Site Selection MRNA Export From Nucleus RNA Splicing Gene Expression Regulation Of Keratinocyte Proliferation MRNA 3'-end Processing Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Negative Regulation Of Cell Death Regulation Of Wound Healing
Pathways			mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS		Menarche (age at onset) ( 21102462)
Protein-Protein Interactions		26 interactors: CDK6 HINFP HIPK3 HNRNPA1 IVNS1ABP LUM NGFR NXF1 RBMX RBMXL2 RBMY1A1 RNPS1 SREK1 SRPK1 SRPK2 SRSF10 SRSF2 SRSF3 SRSF4 SRSF6 SRSF9 TNPO3 YTHDC1 YWHAG YWHAZ ZRANB2	14 interactors: APP CLK1 LUC7L2 PPARGC1A RBM10 RNPS1 SF3B4 SREK1 SRPK1 SRSF4 TERF1 TERF2 TOE1 TRA2B
Entrez ID		6434	6431
HPRD ID		04097	09054
Ensembl ID			ENSG00000124193
Uniprot IDs		P62995	Q13247
PDB IDs		2CQC 2KXN 2RRA 2RRB
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing RNA Processing MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome RNA Export From Nucleus Regulation Of MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing MRNA Export From Nucleus MRNA Transport Nuclear Export RNA Transport Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Localization Negative Regulation Of RNA Splicing Nucleocytoplasmic Transport Nuclear Transport Gene Expression Termination Of RNA Polymerase II Transcription Cytoplasmic Transport RNA Metabolic Process DNA-templated Transcription, Termination MRNA 3'-end Processing Intracellular Transport RNA 3'-end Processing Spliceosomal Complex Assembly Nucleobase-containing Compound Metabolic Process Establishment Of Localization In Cell Regulation Of Alternative MRNA Splicing, Via Spliceosome Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process MRNA Splice Site Selection Cellular Localization Ribonucleoprotein Complex Assembly Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death Regulation Of Metabolic Process Metabolic Process	MRNA Processing MRNA Metabolic Process RNA Processing RNA Splicing Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nitrogen Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication RNA Metabolic Process Telomeric Loop Formation Age-dependent Telomere Shortening Gene Expression Telomere Maintenance Via Telomere Shortening Replicative Cell Aging MRNA 3'-end Processing Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA 3'-end Processing Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Telomere Maintenance Negative Regulation Of RNA Splicing RNA-dependent DNA Replication Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Telomere Maintenance Via Telomere Lengthening Positive Regulation Of RNA Splicing Regulation Of Chromosome Organization Termination Of RNA Polymerase II Transcription Negative Regulation Of DNA Replication Negative Regulation Of Cellular Metabolic Process Cellular Response To Nitrite MRNA Export From Nucleus DNA-templated Transcription, Termination Cell Aging RNA Export From Nucleus Regulation Of RNA Metabolic Process Telomere Maintenance Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Chromosome Organization
Tagcloud ?		3r 4r annonacin attractive brains characterised depending excess exists exon far intervene isoforms link microtubule mitochondrial neurodegenerative others palsy predominant prototypical psp repeat splicing srsf2 supranuclear tau upstream whilst	a1 a1b a2 anchorage b1 constitutive dominant egf elevating erk erk1 hcc hepatocellular hnrnp immortalized isoform knockdown mapk mek oncogenes overexpressing progenitor raf ras regulates splicing srsf1 switch transcript
Tagcloud (Difference) ?		3r 4r annonacin attractive brains characterised depending excess exists exon far intervene isoforms link microtubule mitochondrial neurodegenerative others palsy predominant prototypical psp repeat srsf2 supranuclear tau upstream whilst	a1 a1b a2 anchorage b1 constitutive dominant egf elevating erk erk1 hcc hepatocellular hnrnp immortalized isoform knockdown mapk mek oncogenes overexpressing progenitor raf ras regulates srsf1 switch transcript
Tagcloud (Intersection) ?		splicing