TRA2B and HNRNPA1

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical, two hybrid)

		TRA2B	HNRNPA1
Description		transformer 2 beta homolog	heterogeneous nuclear ribonucleoprotein A1
Image
GO Annotations	Cellular Component	Nucleus Nuclear Inner Membrane Nucleoplasm Spliceosomal Complex Protein-containing Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Membrane Synapse Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Protein Domain Specific Binding Pre-mRNA Binding Identical Protein Binding	Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding Single-stranded RNA Binding MRNA 3'-UTR Binding Protein Binding Protein Domain Specific Binding MiRNA Binding Pre-mRNA Binding Identical Protein Binding Telomeric Repeat-containing RNA Binding G-rich Strand Telomeric DNA Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Cerebral Cortex Regionalization Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Cellular Response To Glucose Stimulus Embryonic Brain Development	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus RNA Splicing Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Response To Glucose Starvation Regulation Of RNA Splicing MRNA Transport Nuclear Export Import Into Nucleus Cellular Response To Sodium Arsenite
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle	FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA SARS-CoV-1-host interactions SARS-CoV-1 modulates host translation machinery
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Height ( 31562340) Menarche (age at onset) ( 21102462 25231870 27182965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)	Meat-related diet ( 32066663) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		107 interacting genes: - CDK6 CLK1 CLK3 EPM2AIP1 HINFP HIPK3 HNRNPA1 IVNS1ABP LUM MAGOHB MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYPOP NGFR NXF1 PCDHB14 RBMX RBMXL2 RBMY1A1 RBMY1F RBMY1J RNPS1 SREK1 SRPK1 SRSF10 SRSF2 SRSF3 SRSF4 SRSF8 SRSF9 TNPO3 U2AF1 YTHDC1 YWHAG YWHAZ ZRANB2	120 interacting genes: ABHD16A APP BCL2L1 CALCOCO2 CCDC50 CEBPA CLK1 DANCR ERG ESR1 FEN1 H3-4 H3C1 HIPK3 HMGA1 HNRNPH3 KHSRP MARCHF8 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NFKBIA NR0B2 NR3C1 OGT PABPN1 PHYHIP PPIL1 PRKDC PRMT1 PRMT2 PRMT3 PRRC2A PSMD9 PTEN RNF14 RPL21 RPS6KB2 SAFB SREK1 SRPK1 SRPK2 SUFU TFEC TNPO1 TRA2B TRAF6 TSHR TTF2 XIAP XRN1
Entrez ID		6434	3178
HPRD ID		04097	01242
Ensembl ID		ENSG00000136527	ENSG00000135486
Uniprot IDs		P62995	A0A024RB53 P09651
PDB IDs		2CQC 2KXN 2RRA 2RRB	1HA1 1L3K 1PGZ 1PO6 1U1K 1U1L 1U1M 1U1N 1U1O 1U1P 1U1Q 1U1R 1UP1 2H4M 2LYV 2UP1 4YOE 5MPG 5MPL 5ZGD 5ZGL 6BXX 6DCL 6J60 7BX7 7ZJ2 8IK7 8IKB 8IKP 8IKS 8RZV 8X0N 9F1S 9F4D 9F4G 9F4H 9F4J 9F4K 9F4L 9F4N 9F4O 9F4P 9F4Q 9F4R 9F4S 9F4T 9F4U 9F4V 9F4W 9F4X 9F4Y 9F4Z 9F50 9F51 9F52 9F53 9F54 9F55 9F5C 9F5D 9F5E 9F5F 9F5G 9F5K 9F7F 9F7H 9GEA 9GPJ 9HQ9 9HQJ 9HQL
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Extracellular Vesicle Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Regulation Of Metabolic Process Positive Regulation Of MRNA Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Locomotion Negative Regulation Of Cytokine Production Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Negative Regulation Of Protein Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Developmental Process Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Space Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of Translation Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Locomotion Negative Regulation Of Protein Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Regulation Of MRNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration
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