TRA2B and LUM

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		TRA2B	LUM
Gene Name		transformer 2 beta homolog (Drosophila)	lumican
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Extracellular Region Proteinaceous Extracellular Matrix Fibrillar Collagen Trimer Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding MRNA Binding Protein Binding Poly(A) RNA Binding	Extracellular Matrix Structural Constituent Protein Binding Collagen Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome	Carbohydrate Metabolic Process Visual Perception Pathogenesis Response To Organic Cyclic Compound Keratan Sulfate Biosynthetic Process Extracellular Matrix Organization Collagen Fibril Organization Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cartilage Development Response To Growth Factor
Pathways			MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome Keratan sulfate/keratin metabolism MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Glycogen storage diseases Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D MPS IIIC - Sanfilippo syndrome C Keratan sulfate biosynthesis Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Keratan sulfate degradation Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Integrin cell surface interactions Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Menarche (age at onset) ( 21102462)	Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		26 interactors: CDK6 HINFP HIPK3 HNRNPA1 IVNS1ABP LUM NGFR NXF1 RBMX RBMXL2 RBMY1A1 RNPS1 SREK1 SRPK1 SRPK2 SRSF10 SRSF2 SRSF3 SRSF4 SRSF6 SRSF9 TNPO3 YTHDC1 YWHAG YWHAZ ZRANB2	5 interactors: ACAN COL1A2 GNAQ MMP14 TRA2B
Entrez ID		6434	4060
HPRD ID		04097	02793
Ensembl ID
Uniprot IDs		P62995	P51884
PDB IDs		2CQC 2KXN 2RRA 2RRB
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing RNA Processing MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome RNA Export From Nucleus Regulation Of MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing MRNA Export From Nucleus MRNA Transport Nuclear Export RNA Transport Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Localization Negative Regulation Of RNA Splicing Nucleocytoplasmic Transport Nuclear Transport Gene Expression Termination Of RNA Polymerase II Transcription Cytoplasmic Transport RNA Metabolic Process DNA-templated Transcription, Termination MRNA 3'-end Processing Intracellular Transport RNA 3'-end Processing Spliceosomal Complex Assembly Nucleobase-containing Compound Metabolic Process Establishment Of Localization In Cell Regulation Of Alternative MRNA Splicing, Via Spliceosome Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process MRNA Splice Site Selection Cellular Localization Ribonucleoprotein Complex Assembly Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death Regulation Of Metabolic Process Metabolic Process	Extracellular Matrix Disassembly Skeletal System Development Extracellular Matrix Organization Extracellular Structure Organization Collagen Fibril Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cardiovascular System Development Anatomical Structure Morphogenesis Platelet Activation Organ Morphogenesis Organ Development Skeletal System Morphogenesis Astrocyte Cell Migration Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Chondrocyte Proliferation Keratan Sulfate Catabolic Process Protein Heterotrimerization Regulation Of Melanocyte Differentiation Blood Coagulation Hemostasis Maternal Behavior Craniofacial Suture Morphogenesis Endothelial Cell Proliferation Catabolic Process System Development Negative Regulation Of Focal Adhesion Assembly Blood Vessel Development Regulation Of Catenin Import Into Nucleus Vasculature Development Regulation Of Developmental Pigmentation Keratan Sulfate Biosynthetic Process Cartilage Condensation Regulation Of Body Fluid Levels Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome Keratan Sulfate Metabolic Process Wound Healing Neuron Maturation Multicellular Organismal Development Embryonic Morphogenesis Chondrocyte Development Protein Trimerization Positive Regulation Of RNA Splicing Dopamine Receptor Signaling Pathway Anatomical Structure Development Cell Activation
Tagcloud ?		3r 4r annonacin attractive brains characterised depending excess exists exon far intervene isoforms link microtubule mitochondrial neurodegenerative others palsy predominant prototypical psp repeat splicing srsf2 supranuclear tau upstream whilst	clone cloned consists designated differed entry herpesvirus hvem immunomodulatory jun leukocytes lymphocyte marked mediator montgomery predominant spear spleen tag tnfr traf traf1 traf2 traf3 traf5 traf6 trafs transfection warner
Tagcloud (Difference) ?		3r 4r annonacin attractive brains characterised depending excess exists exon far intervene isoforms link microtubule mitochondrial neurodegenerative others palsy prototypical psp repeat splicing srsf2 supranuclear tau upstream whilst	clone cloned consists designated differed entry herpesvirus hvem immunomodulatory jun leukocytes lymphocyte marked mediator montgomery spear spleen tag tnfr traf traf1 traf2 traf3 traf5 traf6 trafs transfection warner
Tagcloud (Intersection) ?		predominant