DPAGT1 and CXCR5

Data Source: HiPPIP (Novel)

		DPAGT1	CXCR5
Name		dolichyl-phosphate N-acetylglucosaminephosphotransferase 1	C-X-C motif chemokine receptor 5
Structure			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Intracellular Membrane-bounded Organelle	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Identical Protein Binding Metal Ion Binding	G Protein-coupled Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process	Chemotaxis Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Leukocyte Chemotaxis Positive Regulation Of Cytokinesis B Cell Activation Lymph Node Development Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective DPAGT1 causes CDG-1j, CMSTA2	Chemokine receptors bind chemokines G alpha (i) signalling events
Diseases		Congenital disorders of glycosylation (CDG) type I	None
GWAS		Estimated glomerular filtration rate ( 31152163 ) Lymphocyte percentage of white cells ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 )	Albumin-globulin ratio ( 29403010 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Allergy ( 27182965 ) Asthma ( 34103634 32296059 31959851 30929738 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 30929738 31036433 ) Asthma onset (childhood vs adult) ( 30929738 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Follicular lymphoma ( 25279986 ) Human herpes virus 7 U14 antibody levels ( 33204752 ) Inflammatory bowel disease ( 23128233 ) Multiple sclerosis ( 21833088 24076602 ) Post-bronchodilator lung function in asthma (FVC) ( 32989782 ) Primary biliary cholangitis ( 21399635 26394269 28425483 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 30423114 24390342 ) Sjögren's syndrome ( 24097067 ) Systemic lupus erythematosus ( 32771030 ) Trunk fat mass ( 28552196 ) Vitiligo ( 22951725 )
Novel Interactors		5 novel interactors: CXCR5 ETS1 THTPA TUBE1 WDR5	6 novel interactors: ARCN1 CBL DPAGT1 MRE11 PLS3 TLK1
Interacting Genes		2 interacting genes: LSM8 SLC33A2	1 interacting genes: CXCL13
Entrez ID		1798	643
HPRD ID		01879	03367
Ensembl ID		ENSG00000172269	ENSG00000160683
Uniprot IDs		A0A804HI18 A0A804HKZ3 Q9H3H5	A0N0R2 A8K647 P32302 Q2YD84
PDB IDs		5LEV 5O5E 6BW5 6BW6 6FM9 6FWZ 6JQ3	Not available
GO Terms Enriched among Interactors		None	Regulation Of Rap Protein Signal Transduction UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity Mitochondrial Double-strand Break Repair Via Homologous Recombination Structural Constituent Of Presynaptic Actin Cytoskeleton CXCR5 Chemokine Receptor Binding Lymphocyte Chemotaxis Across High Endothelial Venule Endothelial Cell Chemotaxis To Fibroblast Growth Factor Cerebellar Purkinje Cell Layer Maturation UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Negative Regulation Of Cell Chemotaxis To Fibroblast Growth Factor CCR10 Chemokine Receptor Binding Ubiquitin-dependent Endocytosis Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Meiotic DNA Double-strand Break Formation Mre11 Complex BRCA1-C Complex Chromosomal Region Telomeric 3' Overhang Formation Presynaptic Actin Cytoskeleton Organization Actin Filament Network Formation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin CXCR3 Chemokine Receptor Binding Negative Regulation Of Endothelial Cell Chemotaxis B Cell Chemotaxis DNA Damage Response Regulation Of Mitotic Recombination Presynaptic Cytoskeleton Organization Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor