DPAGT1

Gene Name		dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity Phospho-N-acetylmuramoyl-pentapeptide-transferase Activity Transferase Activity, Transferring Glycosyl Groups
	Biological Process	Polysaccharide Biosynthetic Process UDP-N-acetylglucosamine Metabolic Process Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Dolichol Biosynthetic Process Post-translational Protein Modification Cellular Protein Metabolic Process Protein Oligomerization
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: LSM8 MFSD3
Entrez ID		1798
HPRD ID		01879
Ensembl ID		ENSG00000172269
Uniprot IDs		E7EW40 Q9H3H5
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?		acetylcholine alg13 alg14 alg2 alg2p analogy asparagine catalyses cholinesterase committed concentrated congenital endplates exome fatigable girdle glycosylation inherited kinships mannosyltransferase multiglycosyltransferase multisystem myasthenic neuromuscular synapse underscores val68gly weakness wider