PRCC and MAD2L2

Number of citations of the paper that reports this interaction (PMID 11717438)
8

Data Source:
BioGRID (fluorescent resonance energy transfer)
HPRD (in vitro, in vivo)

		PRCC	MAD2L2
Gene Name		papillary renal cell carcinoma (translocation-associated)	MAD2 mitotic arrest deficient-like 2 (yeast)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Spindle Zeta DNA Polymerase Complex
	Molecular Function	Protein Binding	RNA Polymerase II Activating Transcription Factor Binding Protein Binding JUN Kinase Binding
	Biological Process	Mitotic Cell Cycle Checkpoint	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Growth DNA Repair Double-strand Break Repair Transcription, DNA-templated Actin Filament Organization Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Cell Division Negative Regulation Of APC-Cdc20 Complex Activity Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways			Translesion synthesis by Pol zeta DNA Damage Bypass Translesion synthesis by DNA polymerases bypassing lesion on DNA template
Drugs
Diseases
GWAS			Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		9 interactors: CSNK2A1 EGFR LSM2 MAD2L2 PPIL2 PRPF19 RBM10 SRSF2 TOE1	22 interactors: ADAM15 ADAM17 ADAM9 CAMK2B CDC20 CDH1 ELK1 IKZF1 KCTD9 MAD2L1 POLDIP2 PRCC PRRC2A RBBP6 REL REV1 REV3L SFI1 TCF4 TRIM27 TRIP13 YY1AP1
Entrez ID		5546	10459
HPRD ID		01562	07246
Ensembl ID		ENSG00000143294	ENSG00000116670
Uniprot IDs		A6NG79 Q92733 Q96FT4	Q9UI95
PDB IDs			3ABD 3ABE 3VU7 4EXT 4GK0 4GK5
Enriched GO Terms of Interacting Partners?		RNA Splicing Negative Regulation Of Protein Catabolic Process MRNA Processing Negative Regulation Of Cell Cycle Gene Expression MRNA Metabolic Process RNA Processing Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Cell Cycle Process Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Alkanesulfonate Metabolic Process Generation Of Catalytic Spliceosome For First Transesterification Step Negative Regulation Of Chromosome Organization Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Process Cell Cycle Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Regulation Of Mitotic Nuclear Division Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Double-strand Break Repair Cellular Metabolic Process Mitotic Cell Cycle Process Mitotic Cell Cycle Checkpoint Heterocycle Metabolic Process Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Activation Of Phospholipase A2 Activity Negative Regulation Of APC-Cdc20 Complex Activity Cellular Aromatic Compound Metabolic Process Protein Polyubiquitination	Cell Cycle Cell Cycle Process Regulation Of Cell Cycle Mitotic Cell Cycle Process Extracellular Matrix Disassembly PMA-inducible Membrane Protein Ectodomain Proteolysis Mitotic Cell Cycle Error-prone Translesion Synthesis Response To Stress Regulation Of Meiosis Regulation Of Meiotic Cell Cycle Activation Of Anaphase-promoting Complex Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cellular Component Organization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Collagen Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Translesion Synthesis Cell Cycle Checkpoint Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Cell Adhesion Mediated By Integrin Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Division Multicellular Organismal Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Synapse Maturation Negative Regulation Of Transferase Activity Membrane Protein Ectodomain Proteolysis Regulation Of Synapse Maturation Postreplication Repair Cellular Response To Stress Proteolysis Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Death Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization Immune System Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Membrane Protein Proteolysis Tissue Development Negative Regulation Of Catalytic Activity Spindle Assembly Checkpoint Positive Regulation Of Protein Metabolic Process Innate Immune Response
Tagcloud ?		1g 4179delct ages bilateral develops e1351 exome germline heterozygosity hit kidneys multifocal nephrectomies nephrectomy ngs nonsilent papillary r1032 r1713h r905q rccs second seizures shower tsc tsc2 tuberous typically	arrested cdk1 configuration eliminated fertility flexible g2 g9a glp h3k27me3 h3k9me2 infertile involves mad2b methyltransferases normally pgc pgcs primordial repressive reprogramming rev7 specification specified stably suppressive switch upregulate waves
Tagcloud (Difference) ?		1g 4179delct ages bilateral develops e1351 exome germline heterozygosity hit kidneys multifocal nephrectomies nephrectomy ngs nonsilent papillary r1032 r1713h r905q rccs second seizures shower tsc tsc2 tuberous typically	arrested cdk1 configuration eliminated fertility flexible g2 g9a glp h3k27me3 h3k9me2 infertile involves mad2b methyltransferases normally pgc pgcs primordial repressive reprogramming rev7 specification specified stably suppressive switch upregulate waves
Tagcloud (Intersection) ?