PRCC and MAD2L2

Number of citations of the paper that reports this interaction (PubMedID 11717438)
41

Data Source:
BioGRID (fluorescent resonance energy transfer)
HPRD (in vitro, in vivo)

		PRCC	MAD2L2
Description		proline rich mitotic checkpoint control factor	mitotic arrest deficient 2 like 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Chromatin Nucleus Nucleoplasm Anaphase-promoting Complex Chromosome Cytoplasm Spindle Cytoskeleton Zeta DNA Polymerase Complex Site Of Double-strand Break
	Molecular Function	Protein Binding	Transcription Corepressor Activity Protein Binding JUN Kinase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Somatic Diversification Of Immunoglobulins Involved In Immune Response DNA Repair Double-strand Break Repair DNA Damage Response Actin Filament Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process Error-prone Translesion Synthesis DNA Damage Response, Signal Transduction Resulting In Transcription Telomere Maintenance In Response To DNA Damage Positive Regulation Of Isotype Switching Positive Regulation Of DNA-templated Transcription Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		mRNA Splicing - Major Pathway	Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI
Drugs
Diseases		Renal cell carcinoma
GWAS		Sjögren's syndrome ( 28076899)	Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		8 interacting genes: CSNK2A1 EGFR HOMER3 MAD2L2 PPIL2 RBM10 SRSF2 TOE1	47 interacting genes: ADAM15 ADAM17 ADAM9 CAMK2B CDC20 CDH1 CIMIP1 DEPDC5 ELK1 FAM217B FTO FZR1 GSC2 IKZF1 IKZF3 INCA1 KCTD9 KRT34 MAD2L1 MAD2L1BP MBD3L1 MYBPC2 PLAGL2 POLDIP2 PPM1B PRCC PRR5L PRRC2A RAB11FIP4 RBBP6 REL REV1 REV3L SFI1 SHLD1 TCF4 THAP6 TRIM27 TRIM54 TRIM7 YPEL3 YY1AP1 ZBED1 ZMYND12 ZNF511 ZNF558 ZNF655
Entrez ID		5546	10459
HPRD ID		01562	07246
Ensembl ID		ENSG00000143294	ENSG00000116670
Uniprot IDs		A0A0S2Z456 Q92733 Q96FT4	Q9UI95
PDB IDs			3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5XPT 5XPU 6BC8 6BCD 6BI7 6K07 6K08 6KEA 6KTO 6M7A 6M7B 6NIF 6VE5 6WS0 6WS5 6WW9 6WWA 7L9P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Catabolic Process Negative Regulation Of Protein Catabolic Process MRNA Metabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleic Acid Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of DNA Repair RNA Metabolic Process Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA Recombination Negative Regulation Of Macromolecule Metabolic Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Metabolic Process Multivesicular Body, Internal Vesicle Lumen RNA Processing RNA Splicing Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Ribosomal Large Subunit Export From Nucleus DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Protein Catabolic Process Regulation Of Chromosome Separation Regulation Of Cell Growth Regulation Of Double-strand Break Repair Via Homologous Recombination Nuclear Speck MRNA Processing Regulation Of Cell Cycle Phase Transition Shc-EGFR Complex PML Body Regulation Of DNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Regulation Of MRNA Splicing, Via Spliceosome Smooth Muscle Cell Apoptotic Process G Protein-coupled Glutamate Receptor Binding Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Chromosome Segregation Negative Regulation Of Biosynthetic Process Positive Regulation Of DNA Repair Epidermal Growth Factor Binding Regulation Of MRNA Processing Nucleic Acid Binding Negative Regulation Of Ribosome Biogenesis	Mitotic Checkpoint Complex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Metal Ion Binding Translesion Synthesis Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Protein Binding Positive Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle DNA Binding DNA Biosynthetic Process Postreplication Repair Error-free Translesion Synthesis Positive Regulation Of Synapse Maturation DNA Synthesis Involved In DNA Repair Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Negative Regulation Of Type I Interferon Production Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Error-prone Translesion Synthesis Regulation Of Mitotic Cell Cycle Ubiquitin Ligase Activator Activity Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle DNA-binding Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Zinc Ion Binding Regulation Of Mitotic Sister Chromatid Separation Regulation Of Nuclear Division Negative Regulation Of Interferon-beta Production Positive Regulation Of Catabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Process Amyloid Precursor Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Separation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Phase Transition SUMO Transferase Activity Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Regulation Of Metabolic Process Sequence-specific DNA Binding
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