ITIH4 and DNAJC1

Number of citations of the paper that reports this interaction (PMID 16271702)
2

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ITIH4	DNAJC1
Gene Name		inter-alpha-trypsin inhibitor heavy chain family, member 4	DnaJ (Hsp40) homolog, subfamily C, member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding	ATPase Activator Activity DNA Binding Chromatin Binding Protein Binding Chaperone Binding
	Biological Process	Acute-phase Response Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process Response To Cytokine	Regulation Of Translation Protein Folding Positive Regulation Of ATPase Activity Negative Regulation Of Proteolysis Regulation Of Protein Secretion
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Immune reponse to smallpox (secreted IL-2) ( 22610502) Schizophrenia ( 21926974) Ulcerative colitis ( 23128233)	Breast cancer ( 23535729) Ovarian cancer ( 23535730)
Protein-Protein Interactions		3 interactors: DNAJC1 GRB2 TP63	4 interactors: ABHD16A HSPA5 ITIH4 SERPINA3
Entrez ID		3700	64215
HPRD ID		02781	09922
Ensembl ID		ENSG00000055955	ENSG00000136770
Uniprot IDs		B2RMS9 B7ZKJ8 Q14624	Q96KC8
PDB IDs			2CQQ 2CQR
Enriched GO Terms of Interacting Partners?		Signal Transduction In Response To DNA Damage Cellular Response To Radiation Response To Ionizing Radiation Ectoderm And Mesoderm Interaction Epidermal Cell Division Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Epidermal Cell Division Female Genitalia Morphogenesis Aging Cloacal Septation Urinary Bladder Development Positive Regulation Of Fibroblast Apoptotic Process Cloaca Development Prostatic Bud Formation Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Mesoderm Development Positive Regulation Of Keratinocyte Proliferation Polarized Epithelial Cell Differentiation Protein Oligomerization Response To Radiation Replicative Cell Aging Negative Regulation Of Cellular Senescence Lateral Sprouting From An Epithelium Negative Regulation Of Epidermal Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Reproductive Structure Development Reproductive System Development Morphogenesis Of An Epithelium DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Cell Aging Regulation Of Body Fluid Levels Keratinocyte Proliferation Establishment Of Skin Barrier Establishment Of Planar Polarity Embryonic Morphogenesis Tissue Morphogenesis Epithelial Cell Differentiation Involved In Prostate Gland Development Regulation Of Proteolysis Genitalia Morphogenesis Regulation Of Water Loss Via Skin Post-anal Tail Morphogenesis Regulation Of Fibroblast Apoptotic Process Developmental Process Involved In Reproduction Regulation Of Keratinocyte Proliferation Labyrinthine Layer Morphogenesis Female Genitalia Development Sympathetic Nervous System Development	Acute-phase Response Acute Inflammatory Response Regulation Of Protein Folding In Endoplasmic Reticulum Cerebellum Structural Organization Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity ER Overload Response Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Maintenance Of Protein Localization In Endoplasmic Reticulum Inflammatory Response Regulation Of Cellular Protein Metabolic Process Maintenance Of Gastrointestinal Epithelium Regulation Of Protein Metabolic Process Cellular Response To Antibiotic Epithelial Structure Maintenance Anatomical Structure Arrangement Regulation Of Catalytic Activity Cellular Response To Toxic Substance Cellular Response To Glucose Starvation Regulation Of Proteolysis Response To Cytokine Cerebellar Purkinje Cell Layer Development Negative Regulation Of Catalytic Activity Substantia Nigra Development Hyaluronan Metabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Toxin Transport Cellular Response To Interleukin-4 Negative Regulation Of Protein Metabolic Process Response To Interleukin-4 Cerebellum Morphogenesis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Neural Nucleus Development Hindbrain Morphogenesis Positive Regulation Of Nuclease Activity Response To Antibiotic Response To Stress Cerebellar Cortex Development Platelet Degranulation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Tagcloud ?		arranged borders ccaat consists cotransfection direction dnase duplication ebp ebpalpha ebpbeta exon exons footprinting h1 heavy hepg2 intron inversion itih1 itih3 kilobase opposite pair rounds shares transcribed trypsin	10p12 af10 blasts bmi1 break calm centromeric comm commd3 enrichment gives homolog hsp40 immediately insertion leukemias leukemic lymphoblastic mlv mo p12 q14 recurring semiquantitative spag6 sperm striking subfamily transcriptase
Tagcloud (Difference) ?		arranged borders ccaat consists cotransfection direction dnase duplication ebp ebpalpha ebpbeta exon exons footprinting h1 heavy hepg2 intron inversion itih1 itih3 kilobase opposite pair rounds shares transcribed trypsin	10p12 af10 blasts bmi1 break calm centromeric comm commd3 enrichment gives homolog hsp40 immediately insertion leukemias leukemic lymphoblastic mlv mo p12 q14 recurring semiquantitative spag6 sperm striking subfamily transcriptase
Tagcloud (Intersection) ?