ITIH4 and TP63

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ITIH4	TP63
Gene Name		inter-alpha-trypsin inhibitor heavy chain family, member 4	tumor protein p63
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle	Chromatin Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Rough Endoplasmic Reticulum Cytosol Dendrite
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding	Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription P53 Binding DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding WW Domain Binding
	Biological Process	Acute-phase Response Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process Response To Cytokine	Negative Regulation Of Transcription From RNA Polymerase II Promoter Replicative Cell Aging Skeletal System Development Establishment Of Planar Polarity Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Development Chromatin Remodeling Transcription, DNA-templated Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Notch Signaling Pathway Spermatogenesis Ectoderm And Mesoderm Interaction Proximal/distal Pattern Formation Response To X-ray Multicellular Organismal Aging Response To Gamma Radiation Epidermal Cell Division Regulation Of Epidermal Cell Division Positive Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Embryonic Limb Morphogenesis Polarized Epithelial Cell Differentiation Hair Follicle Morphogenesis Mitotic G1 DNA Damage Checkpoint Cellular Response To UV Post-anal Tail Morphogenesis Odontogenesis Of Dentin-containing Tooth Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Neuron Apoptotic Process Keratinocyte Proliferation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Sympathetic Nervous System Development Smooth Muscle Tissue Development Female Genitalia Morphogenesis Protein Homotetramerization Neuron Apoptotic Process Urinary Bladder Development Cloacal Septation Prostatic Bud Formation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Establishment Of Skin Barrier Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Mesoderm Development Negative Regulation Of Cellular Senescence Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Immune reponse to smallpox (secreted IL-2) ( 22610502) Schizophrenia ( 21926974) Ulcerative colitis ( 23128233)	Acute lymphoblastic leukemia (childhood) ( 22076464) Bladder cancer ( 20972438) Brain imaging ( 20100581) Lung adenocarcinoma ( 22797724 20871597) Lung cancer ( 21725308 23143601) Urinary bladder cancer ( 20348956 18794855)
Protein-Protein Interactions		3 interactors: DNAJC1 GRB2 TP63	32 interactors: BAG6 BTRC CCNC CDKN2A COPS6 DAXX EMX1 EP300 GCGR GNB2L1 GRB2 HIPK2 HNRNPAB HP HPX ITIH4 KAT2B MDM4 NIPSNAP3A ORM1 PINX1 PML PPP1R13B PPP2R5A RCHY1 SCAF4 SLC35A3 TP53 TP73 UBE2I WT1 YAP1
Entrez ID		3700	8626
HPRD ID		02781	04469
Ensembl ID		ENSG00000055955	ENSG00000073282
Uniprot IDs		B2RMS9 B7ZKJ8 Q14624	C9D7D0 Q9H3D4
PDB IDs			1RG6 2RMN 2Y9T 2Y9U 3QYM 3QYN 3US0 3US1 3US2 3ZY0 3ZY1 4A9Z
Enriched GO Terms of Interacting Partners?		Signal Transduction In Response To DNA Damage Cellular Response To Radiation Response To Ionizing Radiation Ectoderm And Mesoderm Interaction Epidermal Cell Division Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Epidermal Cell Division Female Genitalia Morphogenesis Aging Cloacal Septation Urinary Bladder Development Positive Regulation Of Fibroblast Apoptotic Process Cloaca Development Prostatic Bud Formation Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Mesoderm Development Positive Regulation Of Keratinocyte Proliferation Polarized Epithelial Cell Differentiation Protein Oligomerization Response To Radiation Replicative Cell Aging Negative Regulation Of Cellular Senescence Lateral Sprouting From An Epithelium Negative Regulation Of Epidermal Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Reproductive Structure Development Reproductive System Development Morphogenesis Of An Epithelium DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Cell Aging Regulation Of Body Fluid Levels Keratinocyte Proliferation Establishment Of Skin Barrier Establishment Of Planar Polarity Embryonic Morphogenesis Tissue Morphogenesis Epithelial Cell Differentiation Involved In Prostate Gland Development Regulation Of Proteolysis Genitalia Morphogenesis Regulation Of Water Loss Via Skin Post-anal Tail Morphogenesis Regulation Of Fibroblast Apoptotic Process Developmental Process Involved In Reproduction Regulation Of Keratinocyte Proliferation Labyrinthine Layer Morphogenesis Female Genitalia Development Sympathetic Nervous System Development	Negative Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Signal Transduction By P53 Class Mediator Viral Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Regulation Of Metabolic Process Signal Transduction In Response To DNA Damage Cell Cycle Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Gene Expression Cell Cycle Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Modification Process Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Regulation Of Protein Stability Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Cell Death Death Regulation Of Catalytic Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Mitotic Cell Cycle Process Protein Stabilization Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Mitotic Cell Cycle Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Gamma Radiation Negative Regulation Of Growth Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction Resulting In Transcription
Tagcloud ?		arranged borders ccaat consists cotransfection direction dnase duplication ebp ebpalpha ebpbeta exon exons footprinting h1 heavy hepg2 intron inversion itih1 itih3 kilobase opposite pair rounds shares transcribed trypsin	adenocarcinomas advantages ago aiding apply complexity discrepant emerge emphasize experimentally generalisations gives haematological isoform lymphomas methodologies mis np63 np73 p73 reagents sense sometimes tap63 tap73 themes translocations universally
Tagcloud (Difference) ?		arranged borders ccaat consists cotransfection direction dnase duplication ebp ebpalpha ebpbeta exon exons footprinting h1 heavy hepg2 intron inversion itih1 itih3 kilobase opposite pair rounds shares transcribed trypsin	adenocarcinomas advantages ago aiding apply complexity discrepant emerge emphasize experimentally generalisations gives haematological isoform lymphomas methodologies mis np63 np73 p73 reagents sense sometimes tap63 tap73 themes translocations universally
Tagcloud (Intersection) ?