ELSPBP1 and TAL1

Number of citations of the paper that reports this interaction (PubMedID 8159721)
40

Data Source:
HPRD (in vivo, two hybrid)

		ELSPBP1	TAL1
Description		epididymal sperm binding protein 1	TAL bHLH transcription factor 1, erythroid differentiation factor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cell Surface	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Protein-containing Complex
	Molecular Function	Heparin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Histone Deacetylase Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding
	Biological Process	Single Fertilization Sperm Capacitation	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Locomotory Behavior Spinal Cord Association Neuron Differentiation Central Nervous System Neuron Differentiation Hemopoiesis Myeloid Cell Differentiation Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Positive Regulation Of Protein-containing Complex Assembly Embryonic Hemopoiesis Megakaryocyte Development Regulation Of Cell Population Proliferation Erythrocyte Maturation Cell Fate Commitment Regulation Of Myeloid Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Generation Of Neurons Positive Regulation Of Cell Division Astrocyte Fate Commitment Definitive Hemopoiesis Hemangioblast Cell Differentiation Hematopoietic Stem Cell Differentiation Regulation Of Mast Cell Differentiation Regulation Of Somatic Stem Cell Population Maintenance Positive Regulation Of Chromatin Organization
Pathways			RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis
Drugs		N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Intelligence ( 22449649) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Refractive error ( 32231278)	Adult body size ( 32376654) Body mass index ( 25673413) Clozapine-induced agranulocytosis ( 25187353) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		4 interacting genes: MYOD1 NEDD9 PSMD9 TAL1	23 interacting genes: CHD3 DRG1 ELSPBP1 EP300 GATA1 GATA2 GATA3 HDAC1 HOXB9 KAT2B KDM1A LMO1 LMO2 MAPK3 NCAPG2 PRKCQ SIN3A SKP2 SP1 STUB1 TCF3 TCF4 ZHX1
Entrez ID		64100	6886
HPRD ID		12119	01753
Ensembl ID		ENSG00000169393	ENSG00000162367
Uniprot IDs		A0A384NKL6 Q96BH3	P17542 Q16509
PDB IDs			2YPA 2YPB
Enriched GO Terms of Interacting Partners?		BHLH Transcription Factor Binding E-box Binding Transcription Regulator Complex Protein Dimerization Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Organization Myoblast Fate Determination Positive Regulation Of SnRNA Transcription By RNA Polymerase II Regulation Of Cell Development Skeletal Muscle Fiber Adaptation Negative Regulation Of Myoblast Proliferation Positive Regulation Of Skeletal Muscle Tissue Regeneration Positive Regulation Of Cell Differentiation Cell Fate Commitment Myotube Differentiation Involved In Skeletal Muscle Regeneration RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Myeloid Cell Differentiation Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Dendritic Spine Maintenance Positive Regulation Of Immunological Synapse Formation Positive Regulation Of Myeloid Cell Differentiation Proteasome Regulatory Particle Assembly Regulation Of Mast Cell Differentiation Hemangioblast Cell Differentiation Positive Regulation Of Chromatin Organization Basophil Differentiation Astrocyte Fate Commitment Positive Regulation Of Metabolic Process Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Tissue Regeneration Positive Regulation Of Developmental Process Transcription By RNA Polymerase II Glial Cell Fate Commitment Regulation Of Multicellular Organismal Development Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Skeletal Muscle Fiber Development Regulation Of Cell Differentiation Cilium Disassembly Proteasome Regulatory Particle, Base Subcomplex Proteasome Regulatory Particle Spinal Cord Association Neuron Differentiation Regulation Of Somatic Stem Cell Population Maintenance Regulation Of Dendritic Spine Maintenance Megakaryocyte Differentiation Enzyme Binding Muscle Cell Fate Commitment Proteasome Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process BHLH Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Chromatin Binding Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Cell Population Proliferation Transcription Coactivator Binding Regulation Of Multicellular Organismal Process E-box Binding Transcription Cis-regulatory Region Binding DNA-templated Transcription Positive Regulation Of Cell Differentiation Regulation Of Programmed Cell Death Transcription Repressor Complex Eosinophil Fate Commitment Negative Regulation Of Programmed Cell Death Regulation Of Primitive Erythrocyte Differentiation Positive Regulation Of Cell Population Proliferation DNA-binding Transcription Factor Activity P53 Binding Cell Fate Commitment Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
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